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Cutaneous Adverse Drug Reactions in Dogs Treated with Antiepileptic Drugs

Epilepsy is one of the most common neurologic disorders in dogs and life-long treatment with antiepileptic drugs (AED) is frequently required. Adverse events of AED targeting the skin are only rarely reported in veterinary medicine and the true incidence and spectrum of cutaneous reactions in epilep...

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Autores principales: Koch, Tina, Mueller, Ralf S., Dobenecker, Britta, Fischer, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830846/
https://www.ncbi.nlm.nih.gov/pubmed/27148543
http://dx.doi.org/10.3389/fvets.2016.00027
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author Koch, Tina
Mueller, Ralf S.
Dobenecker, Britta
Fischer, Andrea
author_facet Koch, Tina
Mueller, Ralf S.
Dobenecker, Britta
Fischer, Andrea
author_sort Koch, Tina
collection PubMed
description Epilepsy is one of the most common neurologic disorders in dogs and life-long treatment with antiepileptic drugs (AED) is frequently required. Adverse events of AED targeting the skin are only rarely reported in veterinary medicine and the true incidence and spectrum of cutaneous reactions in epileptic dogs remains unknown. In this study, we hypothesized that cutaneous reactions commonly occur in epileptic dogs and are related to AED treatment. A retrospective case review of 185 dogs treated for epilepsy identified 20.0% with simultaneous appearance of dermatologic signs. In a subsequent prospective case investigation (n = 137), we identified newly appearing or distinct worsening of skin lesions following initiation of AED therapy in 10.9% of dogs treated for epilepsy (95% CI 6.8–17.7%). Cutaneous lesions were classified as probably drug-induced in 40.0% of these cases. Patch testing and intradermal testing were further investigated as potential diagnostic methods to confirm AED hypersensitivity. They were of high specificity but sensitivity and positive predictive value appeared inappropriate to recommend their routine use in clinical practice.
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spelling pubmed-48308462016-05-04 Cutaneous Adverse Drug Reactions in Dogs Treated with Antiepileptic Drugs Koch, Tina Mueller, Ralf S. Dobenecker, Britta Fischer, Andrea Front Vet Sci Veterinary Science Epilepsy is one of the most common neurologic disorders in dogs and life-long treatment with antiepileptic drugs (AED) is frequently required. Adverse events of AED targeting the skin are only rarely reported in veterinary medicine and the true incidence and spectrum of cutaneous reactions in epileptic dogs remains unknown. In this study, we hypothesized that cutaneous reactions commonly occur in epileptic dogs and are related to AED treatment. A retrospective case review of 185 dogs treated for epilepsy identified 20.0% with simultaneous appearance of dermatologic signs. In a subsequent prospective case investigation (n = 137), we identified newly appearing or distinct worsening of skin lesions following initiation of AED therapy in 10.9% of dogs treated for epilepsy (95% CI 6.8–17.7%). Cutaneous lesions were classified as probably drug-induced in 40.0% of these cases. Patch testing and intradermal testing were further investigated as potential diagnostic methods to confirm AED hypersensitivity. They were of high specificity but sensitivity and positive predictive value appeared inappropriate to recommend their routine use in clinical practice. Frontiers Media S.A. 2016-04-14 /pmc/articles/PMC4830846/ /pubmed/27148543 http://dx.doi.org/10.3389/fvets.2016.00027 Text en Copyright © 2016 Koch, Mueller, Dobenecker and Fischer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Koch, Tina
Mueller, Ralf S.
Dobenecker, Britta
Fischer, Andrea
Cutaneous Adverse Drug Reactions in Dogs Treated with Antiepileptic Drugs
title Cutaneous Adverse Drug Reactions in Dogs Treated with Antiepileptic Drugs
title_full Cutaneous Adverse Drug Reactions in Dogs Treated with Antiepileptic Drugs
title_fullStr Cutaneous Adverse Drug Reactions in Dogs Treated with Antiepileptic Drugs
title_full_unstemmed Cutaneous Adverse Drug Reactions in Dogs Treated with Antiepileptic Drugs
title_short Cutaneous Adverse Drug Reactions in Dogs Treated with Antiepileptic Drugs
title_sort cutaneous adverse drug reactions in dogs treated with antiepileptic drugs
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830846/
https://www.ncbi.nlm.nih.gov/pubmed/27148543
http://dx.doi.org/10.3389/fvets.2016.00027
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