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Genetic control of bacterial biofilms
Nearly all bacterial species, including pathogens, have the ability to form biofilms. Biofilms are defined as structured ecosystems in which microbes are attached to surfaces and embedded in a matrix composed of polysaccharides, eDNA, and proteins, and their development is a multistep process. Bacte...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830867/ https://www.ncbi.nlm.nih.gov/pubmed/26294280 http://dx.doi.org/10.1007/s13353-015-0309-2 |
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author | Wolska, Krystyna I. Grudniak, Anna M. Rudnicka, Zofia Markowska, Katarzyna |
author_facet | Wolska, Krystyna I. Grudniak, Anna M. Rudnicka, Zofia Markowska, Katarzyna |
author_sort | Wolska, Krystyna I. |
collection | PubMed |
description | Nearly all bacterial species, including pathogens, have the ability to form biofilms. Biofilms are defined as structured ecosystems in which microbes are attached to surfaces and embedded in a matrix composed of polysaccharides, eDNA, and proteins, and their development is a multistep process. Bacterial biofilms constitute a large medical problem due to their extremely high resistance to various types of therapeutics, including conventional antibiotics. Several environmental and genetic signals control every step of biofilm development and dispersal. From among the latter, quorum sensing, cyclic diguanosine-5’-monophosphate, and small RNAs are considered as the main regulators. The present review describes the control role of these three regulators in the life cycles of biofilms built by Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella enterica serovar Typhimurium, and Vibrio cholerae. The interconnections between their activities are shown. Compounds and strategies which target the activity of these regulators, mainly quorum sensing inhibitors, and their potential role in therapy are also assessed. |
format | Online Article Text |
id | pubmed-4830867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-48308672016-04-22 Genetic control of bacterial biofilms Wolska, Krystyna I. Grudniak, Anna M. Rudnicka, Zofia Markowska, Katarzyna J Appl Genet Microbial Genetics • Review Nearly all bacterial species, including pathogens, have the ability to form biofilms. Biofilms are defined as structured ecosystems in which microbes are attached to surfaces and embedded in a matrix composed of polysaccharides, eDNA, and proteins, and their development is a multistep process. Bacterial biofilms constitute a large medical problem due to their extremely high resistance to various types of therapeutics, including conventional antibiotics. Several environmental and genetic signals control every step of biofilm development and dispersal. From among the latter, quorum sensing, cyclic diguanosine-5’-monophosphate, and small RNAs are considered as the main regulators. The present review describes the control role of these three regulators in the life cycles of biofilms built by Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella enterica serovar Typhimurium, and Vibrio cholerae. The interconnections between their activities are shown. Compounds and strategies which target the activity of these regulators, mainly quorum sensing inhibitors, and their potential role in therapy are also assessed. Springer Berlin Heidelberg 2015-08-21 2016 /pmc/articles/PMC4830867/ /pubmed/26294280 http://dx.doi.org/10.1007/s13353-015-0309-2 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Microbial Genetics • Review Wolska, Krystyna I. Grudniak, Anna M. Rudnicka, Zofia Markowska, Katarzyna Genetic control of bacterial biofilms |
title | Genetic control of bacterial biofilms |
title_full | Genetic control of bacterial biofilms |
title_fullStr | Genetic control of bacterial biofilms |
title_full_unstemmed | Genetic control of bacterial biofilms |
title_short | Genetic control of bacterial biofilms |
title_sort | genetic control of bacterial biofilms |
topic | Microbial Genetics • Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830867/ https://www.ncbi.nlm.nih.gov/pubmed/26294280 http://dx.doi.org/10.1007/s13353-015-0309-2 |
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