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Grey Matter Volumes in Children with Conduct Problems and Varying Levels of Callous-Unemotional Traits

Genetic, behavioural and functional neuroimaging studies have revealed that different vulnerabilities characterise children with conduct problems and high levels of callous-unemotional traits (CP/HCU) compared with children with conduct problems and low callous-unemotional traits (CP/LCU). We used v...

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Autores principales: Sebastian, Catherine L., De Brito, Stéphane A., McCrory, Eamon J., Hyde, Zoe H., Lockwood, Patricia L., Cecil, Charlotte A.M., Viding, Essi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830891/
https://www.ncbi.nlm.nih.gov/pubmed/26364620
http://dx.doi.org/10.1007/s10802-015-0073-0
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author Sebastian, Catherine L.
De Brito, Stéphane A.
McCrory, Eamon J.
Hyde, Zoe H.
Lockwood, Patricia L.
Cecil, Charlotte A.M.
Viding, Essi
author_facet Sebastian, Catherine L.
De Brito, Stéphane A.
McCrory, Eamon J.
Hyde, Zoe H.
Lockwood, Patricia L.
Cecil, Charlotte A.M.
Viding, Essi
author_sort Sebastian, Catherine L.
collection PubMed
description Genetic, behavioural and functional neuroimaging studies have revealed that different vulnerabilities characterise children with conduct problems and high levels of callous-unemotional traits (CP/HCU) compared with children with conduct problems and low callous-unemotional traits (CP/LCU). We used voxel-based morphometry to study grey matter volume (GMV) in 89 male participants (aged 10–16), 60 of whom exhibited CP. The CP group was subdivided into CP/HCU (n = 29) and CP/LCU (n = 31). Whole-brain and regional GMV were compared across groups (CP vs. typically developing (TD) controls (n = 29); and CP/HCU vs. CP/LCU vs. TD). Whole-brain analyses showed reduced GMV in left middle frontal gyrus in the CP/HCU group compared with TD controls. Region-of-interest analyses showed reduced volume in bilateral orbitofrontal cortex (OFC) in the CP group as a whole compared with TD controls. Reduced volume in left OFC was found to be driven by the CP/HCU group only, with significant reductions relative to both TD controls and the CP/LCU group, and no difference between these latter two groups. Within the CP group left OFC volume was significantly predicted by CU traits, but not conduct disorder symptoms. Reduced right anterior cingulate cortex volume was also found in CP/HCU compared with TD controls. Our results support previous findings indicating that GMV differences in brain regions central to decision-making and empathy are implicated in CP. However, they extend these data to suggest that some of these differences might specifically characterise the subgroup with CP/HCU, with GMV reduction in left OFC differentiating children with CP/HCU from those with CP/LCU. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10802-015-0073-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-48308912016-04-22 Grey Matter Volumes in Children with Conduct Problems and Varying Levels of Callous-Unemotional Traits Sebastian, Catherine L. De Brito, Stéphane A. McCrory, Eamon J. Hyde, Zoe H. Lockwood, Patricia L. Cecil, Charlotte A.M. Viding, Essi J Abnorm Child Psychol Article Genetic, behavioural and functional neuroimaging studies have revealed that different vulnerabilities characterise children with conduct problems and high levels of callous-unemotional traits (CP/HCU) compared with children with conduct problems and low callous-unemotional traits (CP/LCU). We used voxel-based morphometry to study grey matter volume (GMV) in 89 male participants (aged 10–16), 60 of whom exhibited CP. The CP group was subdivided into CP/HCU (n = 29) and CP/LCU (n = 31). Whole-brain and regional GMV were compared across groups (CP vs. typically developing (TD) controls (n = 29); and CP/HCU vs. CP/LCU vs. TD). Whole-brain analyses showed reduced GMV in left middle frontal gyrus in the CP/HCU group compared with TD controls. Region-of-interest analyses showed reduced volume in bilateral orbitofrontal cortex (OFC) in the CP group as a whole compared with TD controls. Reduced volume in left OFC was found to be driven by the CP/HCU group only, with significant reductions relative to both TD controls and the CP/LCU group, and no difference between these latter two groups. Within the CP group left OFC volume was significantly predicted by CU traits, but not conduct disorder symptoms. Reduced right anterior cingulate cortex volume was also found in CP/HCU compared with TD controls. Our results support previous findings indicating that GMV differences in brain regions central to decision-making and empathy are implicated in CP. However, they extend these data to suggest that some of these differences might specifically characterise the subgroup with CP/HCU, with GMV reduction in left OFC differentiating children with CP/HCU from those with CP/LCU. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10802-015-0073-0) contains supplementary material, which is available to authorized users. Springer US 2015-09-14 2016 /pmc/articles/PMC4830891/ /pubmed/26364620 http://dx.doi.org/10.1007/s10802-015-0073-0 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Sebastian, Catherine L.
De Brito, Stéphane A.
McCrory, Eamon J.
Hyde, Zoe H.
Lockwood, Patricia L.
Cecil, Charlotte A.M.
Viding, Essi
Grey Matter Volumes in Children with Conduct Problems and Varying Levels of Callous-Unemotional Traits
title Grey Matter Volumes in Children with Conduct Problems and Varying Levels of Callous-Unemotional Traits
title_full Grey Matter Volumes in Children with Conduct Problems and Varying Levels of Callous-Unemotional Traits
title_fullStr Grey Matter Volumes in Children with Conduct Problems and Varying Levels of Callous-Unemotional Traits
title_full_unstemmed Grey Matter Volumes in Children with Conduct Problems and Varying Levels of Callous-Unemotional Traits
title_short Grey Matter Volumes in Children with Conduct Problems and Varying Levels of Callous-Unemotional Traits
title_sort grey matter volumes in children with conduct problems and varying levels of callous-unemotional traits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830891/
https://www.ncbi.nlm.nih.gov/pubmed/26364620
http://dx.doi.org/10.1007/s10802-015-0073-0
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