Cargando…

Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts

Marfan syndrome (MFS) is an autosomal dominant genetic disease caused by abnormal formation of the extracellular matrix with an incidence of 1 in 3, 000 to 5, 000. Patients with Marfan syndrome experience poor quality of life caused by skeletal disorders such as scoliosis, and they are at high risk...

Descripción completa

Detalles Bibliográficos
Autores principales: Umeyama, Kazuhiro, Watanabe, Kota, Watanabe, Masahito, Horiuchi, Keisuke, Nakano, Kazuaki, Kitashiro, Masateru, Matsunari, Hitomi, Kimura, Tokuhiro, Arima, Yoshimi, Sampetrean, Oltea, Nagaya, Masaki, Saito, Masahiro, Saya, Hideyuki, Kosaki, Kenjiro, Nagashima, Hiroshi, Matsumoto, Morio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830947/
https://www.ncbi.nlm.nih.gov/pubmed/27074716
http://dx.doi.org/10.1038/srep24413

Ejemplares similares