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Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity

Regulatory T cells (Tregs) expand in peripheral lymphoid organs and can produce immunosuppressive cytokines to support tumor growth. IL-10 abrogation efficiently induces Treg formation but dampens tumoral neuropilin-1 (Nrp-1) Treg signaling, which simultaneously augments Th1 and Th17 immunity. These...

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Detalles Bibliográficos
Autores principales:	Wang, Shimin, Gao, Xiang, Shen, Guobo, Wang, Wei, Li, Jingyu, Zhao, Jingyi, Wei, Yu-Quan, Edwards, Carl K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831052/ https://www.ncbi.nlm.nih.gov/pubmed/27075020 http://dx.doi.org/10.1038/srep24249

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