6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation

BACKGROUND: The pathogenesis of several neurodegenerative diseases often involves the microglial activation and associated inflammatory processes. Activated microglia release pro-inflammatory factors that may be neurotoxic. 6-Mercaptopurine (6-MP) is a well-established immunosuppressive drug. Common...

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Detalles Bibliográficos
Autores principales: Huang, Hsin-Yi, Chang, Hui-Fen, Tsai, Ming-Jen, Chen, Jhih-Si, Wang, Mei-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831152/
https://www.ncbi.nlm.nih.gov/pubmed/27075886
http://dx.doi.org/10.1186/s12974-016-0543-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831152/
https://www.ncbi.nlm.nih.gov/pubmed/27075886
http://dx.doi.org/10.1186/s12974-016-0543-5

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