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Topiramate-induced severe heatstroke in an adult patient: a case report
BACKGROUND: Heatstroke is a life-threatening condition defined by failure of heat load dissipation, resulting in a core temperature higher than 40 °C (104 °F) associated with neurological dysfunction. Topiramate may cause anhidrosis, potentially resulting in heatstroke, as reported especially in chi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831160/ https://www.ncbi.nlm.nih.gov/pubmed/27075033 http://dx.doi.org/10.1186/s13256-016-0835-5 |
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author | Canel, Lucie Zisimopoulou, Sofia Besson, Marie Nendaz, Mathieu |
author_facet | Canel, Lucie Zisimopoulou, Sofia Besson, Marie Nendaz, Mathieu |
author_sort | Canel, Lucie |
collection | PubMed |
description | BACKGROUND: Heatstroke is a life-threatening condition defined by failure of heat load dissipation, resulting in a core temperature higher than 40 °C (104 °F) associated with neurological dysfunction. Topiramate may cause anhidrosis, potentially resulting in heatstroke, as reported especially in children. CASE PRESENTATION: A 57-year-old Caucasian man was admitted to the emergency room in a febrile comatose state. After a complete workup ruling out the usual etiologies of such a condition, we assumed the hypothesis of a heatstroke caused by topiramate, recently prescribed for essential tremor. CONCLUSIONS: Topiramate-related heatstroke has been described in children but must be recognized in adults as well. Outcomes may range from total clinical recovery to persistent neurological dysfunction or death. The prescription of topiramate and the follow-up of adult patients under this medication should include an evaluation of hypohidrosis, especially in contexts of high temperature. |
format | Online Article Text |
id | pubmed-4831160 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48311602016-04-15 Topiramate-induced severe heatstroke in an adult patient: a case report Canel, Lucie Zisimopoulou, Sofia Besson, Marie Nendaz, Mathieu J Med Case Rep Case Report BACKGROUND: Heatstroke is a life-threatening condition defined by failure of heat load dissipation, resulting in a core temperature higher than 40 °C (104 °F) associated with neurological dysfunction. Topiramate may cause anhidrosis, potentially resulting in heatstroke, as reported especially in children. CASE PRESENTATION: A 57-year-old Caucasian man was admitted to the emergency room in a febrile comatose state. After a complete workup ruling out the usual etiologies of such a condition, we assumed the hypothesis of a heatstroke caused by topiramate, recently prescribed for essential tremor. CONCLUSIONS: Topiramate-related heatstroke has been described in children but must be recognized in adults as well. Outcomes may range from total clinical recovery to persistent neurological dysfunction or death. The prescription of topiramate and the follow-up of adult patients under this medication should include an evaluation of hypohidrosis, especially in contexts of high temperature. BioMed Central 2016-04-13 /pmc/articles/PMC4831160/ /pubmed/27075033 http://dx.doi.org/10.1186/s13256-016-0835-5 Text en © Canel et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Canel, Lucie Zisimopoulou, Sofia Besson, Marie Nendaz, Mathieu Topiramate-induced severe heatstroke in an adult patient: a case report |
title | Topiramate-induced severe heatstroke in an adult patient: a case report |
title_full | Topiramate-induced severe heatstroke in an adult patient: a case report |
title_fullStr | Topiramate-induced severe heatstroke in an adult patient: a case report |
title_full_unstemmed | Topiramate-induced severe heatstroke in an adult patient: a case report |
title_short | Topiramate-induced severe heatstroke in an adult patient: a case report |
title_sort | topiramate-induced severe heatstroke in an adult patient: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831160/ https://www.ncbi.nlm.nih.gov/pubmed/27075033 http://dx.doi.org/10.1186/s13256-016-0835-5 |
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