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Random walk of passive tracers among randomly moving obstacles
BACKGROUND: This study is mainly motivated by the need of understanding how the diffusion behavior of a biomolecule (or even of a larger object) is affected by other moving macromolecules, organelles, and so on, inside a living cell, whence the possibility of understanding whether or not a randomly...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831201/ https://www.ncbi.nlm.nih.gov/pubmed/27075996 http://dx.doi.org/10.1186/s12976-016-0038-1 |
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author | Gori, Matteo Donato, Irene Floriani, Elena Nardecchia, Ilaria Pettini, Marco |
author_facet | Gori, Matteo Donato, Irene Floriani, Elena Nardecchia, Ilaria Pettini, Marco |
author_sort | Gori, Matteo |
collection | PubMed |
description | BACKGROUND: This study is mainly motivated by the need of understanding how the diffusion behavior of a biomolecule (or even of a larger object) is affected by other moving macromolecules, organelles, and so on, inside a living cell, whence the possibility of understanding whether or not a randomly walking biomolecule is also subject to a long-range force field driving it to its target. METHOD: By means of the Continuous Time Random Walk (CTRW) technique the topic of random walk in random environment is here considered in the case of a passively diffusing particle among randomly moving and interacting obstacles. RESULTS: The relevant physical quantity which is worked out is the diffusion coefficient of the passive tracer which is computed as a function of the average inter-obstacles distance. CONCLUSIONS: The results reported here suggest that if a biomolecule, let us call it a test molecule, moves towards its target in the presence of other independently interacting molecules, its motion can be considerably slowed down. |
format | Online Article Text |
id | pubmed-4831201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48312012016-04-15 Random walk of passive tracers among randomly moving obstacles Gori, Matteo Donato, Irene Floriani, Elena Nardecchia, Ilaria Pettini, Marco Theor Biol Med Model Research BACKGROUND: This study is mainly motivated by the need of understanding how the diffusion behavior of a biomolecule (or even of a larger object) is affected by other moving macromolecules, organelles, and so on, inside a living cell, whence the possibility of understanding whether or not a randomly walking biomolecule is also subject to a long-range force field driving it to its target. METHOD: By means of the Continuous Time Random Walk (CTRW) technique the topic of random walk in random environment is here considered in the case of a passively diffusing particle among randomly moving and interacting obstacles. RESULTS: The relevant physical quantity which is worked out is the diffusion coefficient of the passive tracer which is computed as a function of the average inter-obstacles distance. CONCLUSIONS: The results reported here suggest that if a biomolecule, let us call it a test molecule, moves towards its target in the presence of other independently interacting molecules, its motion can be considerably slowed down. BioMed Central 2016-04-14 /pmc/articles/PMC4831201/ /pubmed/27075996 http://dx.doi.org/10.1186/s12976-016-0038-1 Text en © Gori et al. 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Gori, Matteo Donato, Irene Floriani, Elena Nardecchia, Ilaria Pettini, Marco Random walk of passive tracers among randomly moving obstacles |
title | Random walk of passive tracers among randomly moving obstacles |
title_full | Random walk of passive tracers among randomly moving obstacles |
title_fullStr | Random walk of passive tracers among randomly moving obstacles |
title_full_unstemmed | Random walk of passive tracers among randomly moving obstacles |
title_short | Random walk of passive tracers among randomly moving obstacles |
title_sort | random walk of passive tracers among randomly moving obstacles |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831201/ https://www.ncbi.nlm.nih.gov/pubmed/27075996 http://dx.doi.org/10.1186/s12976-016-0038-1 |
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