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Random walk of passive tracers among randomly moving obstacles

BACKGROUND: This study is mainly motivated by the need of understanding how the diffusion behavior of a biomolecule (or even of a larger object) is affected by other moving macromolecules, organelles, and so on, inside a living cell, whence the possibility of understanding whether or not a randomly...

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Autores principales: Gori, Matteo, Donato, Irene, Floriani, Elena, Nardecchia, Ilaria, Pettini, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831201/
https://www.ncbi.nlm.nih.gov/pubmed/27075996
http://dx.doi.org/10.1186/s12976-016-0038-1
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author Gori, Matteo
Donato, Irene
Floriani, Elena
Nardecchia, Ilaria
Pettini, Marco
author_facet Gori, Matteo
Donato, Irene
Floriani, Elena
Nardecchia, Ilaria
Pettini, Marco
author_sort Gori, Matteo
collection PubMed
description BACKGROUND: This study is mainly motivated by the need of understanding how the diffusion behavior of a biomolecule (or even of a larger object) is affected by other moving macromolecules, organelles, and so on, inside a living cell, whence the possibility of understanding whether or not a randomly walking biomolecule is also subject to a long-range force field driving it to its target. METHOD: By means of the Continuous Time Random Walk (CTRW) technique the topic of random walk in random environment is here considered in the case of a passively diffusing particle among randomly moving and interacting obstacles. RESULTS: The relevant physical quantity which is worked out is the diffusion coefficient of the passive tracer which is computed as a function of the average inter-obstacles distance. CONCLUSIONS: The results reported here suggest that if a biomolecule, let us call it a test molecule, moves towards its target in the presence of other independently interacting molecules, its motion can be considerably slowed down.
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spelling pubmed-48312012016-04-15 Random walk of passive tracers among randomly moving obstacles Gori, Matteo Donato, Irene Floriani, Elena Nardecchia, Ilaria Pettini, Marco Theor Biol Med Model Research BACKGROUND: This study is mainly motivated by the need of understanding how the diffusion behavior of a biomolecule (or even of a larger object) is affected by other moving macromolecules, organelles, and so on, inside a living cell, whence the possibility of understanding whether or not a randomly walking biomolecule is also subject to a long-range force field driving it to its target. METHOD: By means of the Continuous Time Random Walk (CTRW) technique the topic of random walk in random environment is here considered in the case of a passively diffusing particle among randomly moving and interacting obstacles. RESULTS: The relevant physical quantity which is worked out is the diffusion coefficient of the passive tracer which is computed as a function of the average inter-obstacles distance. CONCLUSIONS: The results reported here suggest that if a biomolecule, let us call it a test molecule, moves towards its target in the presence of other independently interacting molecules, its motion can be considerably slowed down. BioMed Central 2016-04-14 /pmc/articles/PMC4831201/ /pubmed/27075996 http://dx.doi.org/10.1186/s12976-016-0038-1 Text en © Gori et al. 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Gori, Matteo
Donato, Irene
Floriani, Elena
Nardecchia, Ilaria
Pettini, Marco
Random walk of passive tracers among randomly moving obstacles
title Random walk of passive tracers among randomly moving obstacles
title_full Random walk of passive tracers among randomly moving obstacles
title_fullStr Random walk of passive tracers among randomly moving obstacles
title_full_unstemmed Random walk of passive tracers among randomly moving obstacles
title_short Random walk of passive tracers among randomly moving obstacles
title_sort random walk of passive tracers among randomly moving obstacles
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831201/
https://www.ncbi.nlm.nih.gov/pubmed/27075996
http://dx.doi.org/10.1186/s12976-016-0038-1
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