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ADIPOCYTOKINES AND OBESITY-LINKED DISORDERS

Obesity is closely associated with an increased risk for metabolic and cardiovascular diseases. Adipose tissue produces a number of secretory bioactive substances, also known as adipocytokines or adipokines, which directly affect adjacent or distant organs. Most adipocytokines are pro-inflammatory,...

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Detalles Bibliográficos
Autores principales: OUCHI, NORIYUKI, OHASHI, KOJI, SHIBATA, REI, MUROHARA, TOYOAKI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nagoya University 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831247/
https://www.ncbi.nlm.nih.gov/pubmed/22515108
Descripción
Sumario:Obesity is closely associated with an increased risk for metabolic and cardiovascular diseases. Adipose tissue produces a number of secretory bioactive substances, also known as adipocytokines or adipokines, which directly affect adjacent or distant organs. Most adipocytokines are pro-inflammatory, thereby promoting the obesity-linked disorders. In contrast, there are a small number of adipocytokines that exhibit anti-inflammatory properties. It is now recognized that dysregulated production or secretion of adipocytokines caused by adipocyte dysfunction leads to the development of obesity-linked complications. In this review, we focus on the functional role of several adipocytokines in metabolic and cardiovascular diseases.