Cargando…

PROGNOSTIC FACTORS FOR TUMOR RECURRENCE AFTER GAMMA KNIFE RADIOSURGERY OF PARTIALLY RESECTED AND RECURRENT CRANIOPHARYNGIOMAS

A study was conducted to clarify the prognostic factors related to recurrence of craniopharyngioma and to improve the quality of life of patients by the treatment with intentional partial removal and gamma knife radiosurgery. One hundred cases of craniopharyngioma have been treated at Komaki City Ho...

Descripción completa

Detalles Bibliográficos
Autores principales: KOBAYASHI, TATSUYA, MORI, YOSHIMASA, TSUGAWA, TAKAHIKO, HASHIZUME, CHISA, TAKAHASHI, HIROSHI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nagoya University 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831259/
https://www.ncbi.nlm.nih.gov/pubmed/22515120
_version_ 1782427037918560256
author KOBAYASHI, TATSUYA
MORI, YOSHIMASA
TSUGAWA, TAKAHIKO
HASHIZUME, CHISA
TAKAHASHI, HIROSHI
author_facet KOBAYASHI, TATSUYA
MORI, YOSHIMASA
TSUGAWA, TAKAHIKO
HASHIZUME, CHISA
TAKAHASHI, HIROSHI
author_sort KOBAYASHI, TATSUYA
collection PubMed
description A study was conducted to clarify the prognostic factors related to recurrence of craniopharyngioma and to improve the quality of life of patients by the treatment with intentional partial removal and gamma knife radiosurgery. One hundred cases of craniopharyngioma have been treated at Komaki City Hospital since 1991. In a mean follow-up period of 65.5 months, the tumor control rate was 79.5%. The 5- and 10-year actuarial survival rates were 94.1% and 91%, respectively. However, the recurrence-free survival rates were 73.6% at 5 years and 60.2% at 10 years. Nine factors thought to be related to the recurrence were selected from past references and previous studies, including gender, age, pediatric (≤17 years) or adult patient, partial removal or recurrence, mean tumor diameter, tumor type (solid or cyst), pathological types (squamous cell or adamantinoma), number of previous treatments, and radiation dose. Statistical analysis was performed to determine which factors had a significant prognostic impact. Multivariate analysis showed that mean tumor diameter and radiation dose were independent predictors of outcome. To maximize the prognostic power of these factors, cut-off levels were determined using ROC analysis. These levels were 19 mm for tumor diameter and 13.2 Gy for marginal dose. Significant prognostic factors related to recurrence of craniopharyngioma are tumor diameter and radiation dose. A tumor diameter of <19 mm and a marginal dose of ≥13.2 Gy are favorable prognostic factors for gamma knife radiosurgery.
format Online
Article
Text
id pubmed-4831259
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Nagoya University
record_format MEDLINE/PubMed
spelling pubmed-48312592016-04-25 PROGNOSTIC FACTORS FOR TUMOR RECURRENCE AFTER GAMMA KNIFE RADIOSURGERY OF PARTIALLY RESECTED AND RECURRENT CRANIOPHARYNGIOMAS KOBAYASHI, TATSUYA MORI, YOSHIMASA TSUGAWA, TAKAHIKO HASHIZUME, CHISA TAKAHASHI, HIROSHI Nagoya J Med Sci Original Paper A study was conducted to clarify the prognostic factors related to recurrence of craniopharyngioma and to improve the quality of life of patients by the treatment with intentional partial removal and gamma knife radiosurgery. One hundred cases of craniopharyngioma have been treated at Komaki City Hospital since 1991. In a mean follow-up period of 65.5 months, the tumor control rate was 79.5%. The 5- and 10-year actuarial survival rates were 94.1% and 91%, respectively. However, the recurrence-free survival rates were 73.6% at 5 years and 60.2% at 10 years. Nine factors thought to be related to the recurrence were selected from past references and previous studies, including gender, age, pediatric (≤17 years) or adult patient, partial removal or recurrence, mean tumor diameter, tumor type (solid or cyst), pathological types (squamous cell or adamantinoma), number of previous treatments, and radiation dose. Statistical analysis was performed to determine which factors had a significant prognostic impact. Multivariate analysis showed that mean tumor diameter and radiation dose were independent predictors of outcome. To maximize the prognostic power of these factors, cut-off levels were determined using ROC analysis. These levels were 19 mm for tumor diameter and 13.2 Gy for marginal dose. Significant prognostic factors related to recurrence of craniopharyngioma are tumor diameter and radiation dose. A tumor diameter of <19 mm and a marginal dose of ≥13.2 Gy are favorable prognostic factors for gamma knife radiosurgery. Nagoya University 2012-02 /pmc/articles/PMC4831259/ /pubmed/22515120 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Paper
KOBAYASHI, TATSUYA
MORI, YOSHIMASA
TSUGAWA, TAKAHIKO
HASHIZUME, CHISA
TAKAHASHI, HIROSHI
PROGNOSTIC FACTORS FOR TUMOR RECURRENCE AFTER GAMMA KNIFE RADIOSURGERY OF PARTIALLY RESECTED AND RECURRENT CRANIOPHARYNGIOMAS
title PROGNOSTIC FACTORS FOR TUMOR RECURRENCE AFTER GAMMA KNIFE RADIOSURGERY OF PARTIALLY RESECTED AND RECURRENT CRANIOPHARYNGIOMAS
title_full PROGNOSTIC FACTORS FOR TUMOR RECURRENCE AFTER GAMMA KNIFE RADIOSURGERY OF PARTIALLY RESECTED AND RECURRENT CRANIOPHARYNGIOMAS
title_fullStr PROGNOSTIC FACTORS FOR TUMOR RECURRENCE AFTER GAMMA KNIFE RADIOSURGERY OF PARTIALLY RESECTED AND RECURRENT CRANIOPHARYNGIOMAS
title_full_unstemmed PROGNOSTIC FACTORS FOR TUMOR RECURRENCE AFTER GAMMA KNIFE RADIOSURGERY OF PARTIALLY RESECTED AND RECURRENT CRANIOPHARYNGIOMAS
title_short PROGNOSTIC FACTORS FOR TUMOR RECURRENCE AFTER GAMMA KNIFE RADIOSURGERY OF PARTIALLY RESECTED AND RECURRENT CRANIOPHARYNGIOMAS
title_sort prognostic factors for tumor recurrence after gamma knife radiosurgery of partially resected and recurrent craniopharyngiomas
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831259/
https://www.ncbi.nlm.nih.gov/pubmed/22515120
work_keys_str_mv AT kobayashitatsuya prognosticfactorsfortumorrecurrenceaftergammakniferadiosurgeryofpartiallyresectedandrecurrentcraniopharyngiomas
AT moriyoshimasa prognosticfactorsfortumorrecurrenceaftergammakniferadiosurgeryofpartiallyresectedandrecurrentcraniopharyngiomas
AT tsugawatakahiko prognosticfactorsfortumorrecurrenceaftergammakniferadiosurgeryofpartiallyresectedandrecurrentcraniopharyngiomas
AT hashizumechisa prognosticfactorsfortumorrecurrenceaftergammakniferadiosurgeryofpartiallyresectedandrecurrentcraniopharyngiomas
AT takahashihiroshi prognosticfactorsfortumorrecurrenceaftergammakniferadiosurgeryofpartiallyresectedandrecurrentcraniopharyngiomas