EXTRAVASATION OF PEGYLATED-LIPOSOMAL DOXORUBICIN: FAVORABLE OUTCOME AFTER IMMEDIATE SUBCUTANEOUS ADMINISTRATION OF CORTICOSTEROIDS

A massive extravasation of pegylated-liposomal doxorubicin (Doxil(®)) accidentally occurred, affecting the right forearm of a 54-year-old woman with metastatic ovarian cancer who was receiving an intravenous infusion of the drug. In accordance with the institutional guidelines for vesicant drugs, a...

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Detalles Bibliográficos
Autores principales: MITSUMA, AYAKO, SAWAKI, MASATAKA, SHIBATA, TAKASHI, MORITA, SACHI, INADA, MEGUMI, SHIMOKATA, TOMOYA, SUGISHITA, MIHOKO, KITAGAWA, KOICHI, SAWADA, MASAKI, NAWA, AKIHIRO, ANDO, YUICHI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nagoya University 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831265/
https://www.ncbi.nlm.nih.gov/pubmed/22515126
Descripción
Sumario:A massive extravasation of pegylated-liposomal doxorubicin (Doxil(®)) accidentally occurred, affecting the right forearm of a 54-year-old woman with metastatic ovarian cancer who was receiving an intravenous infusion of the drug. In accordance with the institutional guidelines for vesicant drugs, a corticosteroid preparation was immediately injected subcutaneously into the surrounding tissues. Clobetasol propionate and an ice pack were then topically applied to the affected region. There were no serious complications at the extravasation site, such as tissue necrosis or severe pain, and only a transient erythema of the skin and desquamation remained after 2 months.

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