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Interaction with the Paxillin LD1 Motif Relieves MEKK2 Auto-inhibition
The cell signaling molecule MEK kinase 2 (MEKK2) is a key upstream regulator of MAPK activity that regulates numerous cellular functions, but the mechanisms that control MEKK2 activity are not well understood. Recently, we reported that MEKK2 both binds and promotes ubiquitylation of the scaffold pr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Ubiquity Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831274/ https://www.ncbi.nlm.nih.gov/pubmed/27096002 http://dx.doi.org/10.5334/1750-2187-10-4 |