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O‐GlcNAcylation: a bridge between glucose and cell differentiation
Glucose is the major energy supply and a critical metabolite for most cells and is especially important when cell is differentiating. High or low concentrations of glucose enhances or inhibits the osteogenic, chondrogenic and adipogenic differentiation of cell via the insulin, transforming growth fa...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831356/ https://www.ncbi.nlm.nih.gov/pubmed/26929182 http://dx.doi.org/10.1111/jcmm.12807 |
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author | Sun, Chao Shang, Jin Yao, Yuan Yin, Xiaohong Liu, Minghan Liu, Huan Zhou, Yue |
author_facet | Sun, Chao Shang, Jin Yao, Yuan Yin, Xiaohong Liu, Minghan Liu, Huan Zhou, Yue |
author_sort | Sun, Chao |
collection | PubMed |
description | Glucose is the major energy supply and a critical metabolite for most cells and is especially important when cell is differentiating. High or low concentrations of glucose enhances or inhibits the osteogenic, chondrogenic and adipogenic differentiation of cell via the insulin, transforming growth factor‐β and peroxisome proliferator‐activated receptor γ pathways, among others. New evidence implicates the hexosamine biosynthetic pathway as a mediator of crosstalk between glucose flux, cellular signalling and epigenetic regulation of cell differentiation. Extracellular glucose flux alters intracellular O‐GlcNAcylation levels through the hexosamine biosynthetic pathway. Signalling molecules that are important for cell differentiation, including protein kinase C, extracellular signal‐regulated kinase, Runx2, CCAAT/enhancer‐binding proteins, are modified by O‐GlcNAcylation. Thus, O‐GlcNAcylation markedly alters cell fate during differentiation via the post‐transcriptional modification of proteins. Furthermore, O‐GlcNAcylation and phosphorylation show complex interactions during cell differentiation: they can either non‐competitively occupy different sites on a substrate or competitively occupy a single site or proximal sites. Therefore, the influence of glucose on cell differentiation via O‐GlcNAcylation offers a potential target for controlling tissue homoeostasis and regeneration in ageing and disease. Here, we review recent progress establishing an emerging relationship among glucose concentration, O‐GlcNAcylation levels and cell differentiation. |
format | Online Article Text |
id | pubmed-4831356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48313562016-05-01 O‐GlcNAcylation: a bridge between glucose and cell differentiation Sun, Chao Shang, Jin Yao, Yuan Yin, Xiaohong Liu, Minghan Liu, Huan Zhou, Yue J Cell Mol Med Review Articles Glucose is the major energy supply and a critical metabolite for most cells and is especially important when cell is differentiating. High or low concentrations of glucose enhances or inhibits the osteogenic, chondrogenic and adipogenic differentiation of cell via the insulin, transforming growth factor‐β and peroxisome proliferator‐activated receptor γ pathways, among others. New evidence implicates the hexosamine biosynthetic pathway as a mediator of crosstalk between glucose flux, cellular signalling and epigenetic regulation of cell differentiation. Extracellular glucose flux alters intracellular O‐GlcNAcylation levels through the hexosamine biosynthetic pathway. Signalling molecules that are important for cell differentiation, including protein kinase C, extracellular signal‐regulated kinase, Runx2, CCAAT/enhancer‐binding proteins, are modified by O‐GlcNAcylation. Thus, O‐GlcNAcylation markedly alters cell fate during differentiation via the post‐transcriptional modification of proteins. Furthermore, O‐GlcNAcylation and phosphorylation show complex interactions during cell differentiation: they can either non‐competitively occupy different sites on a substrate or competitively occupy a single site or proximal sites. Therefore, the influence of glucose on cell differentiation via O‐GlcNAcylation offers a potential target for controlling tissue homoeostasis and regeneration in ageing and disease. Here, we review recent progress establishing an emerging relationship among glucose concentration, O‐GlcNAcylation levels and cell differentiation. John Wiley and Sons Inc. 2016-03-01 2016-05 /pmc/articles/PMC4831356/ /pubmed/26929182 http://dx.doi.org/10.1111/jcmm.12807 Text en © 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Sun, Chao Shang, Jin Yao, Yuan Yin, Xiaohong Liu, Minghan Liu, Huan Zhou, Yue O‐GlcNAcylation: a bridge between glucose and cell differentiation |
title | O‐GlcNAcylation: a bridge between glucose and cell differentiation |
title_full | O‐GlcNAcylation: a bridge between glucose and cell differentiation |
title_fullStr | O‐GlcNAcylation: a bridge between glucose and cell differentiation |
title_full_unstemmed | O‐GlcNAcylation: a bridge between glucose and cell differentiation |
title_short | O‐GlcNAcylation: a bridge between glucose and cell differentiation |
title_sort | o‐glcnacylation: a bridge between glucose and cell differentiation |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831356/ https://www.ncbi.nlm.nih.gov/pubmed/26929182 http://dx.doi.org/10.1111/jcmm.12807 |
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