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The implications of small stem cell niche sizes and the distribution of fitness effects of new mutations in aging and tumorigenesis
Somatic tissue evolves over a vertebrate's lifetime due to the accumulation of mutations in stem cell populations. Mutations may alter cellular fitness and contribute to tumorigenesis or aging. The distribution of mutational effects within somatic cells is not known. Given the unique regulatory...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831459/ https://www.ncbi.nlm.nih.gov/pubmed/27099622 http://dx.doi.org/10.1111/eva.12361 |