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Role of MicroRNAs in Malignant Glioma
OBJECTIVE: This overview seeked to bring together the microRNA (miRNA) researches on biogenesis and bio-function in these areas of clinical diagnosis and therapy for malignant glioma. DATA SOURCES: Using the keyword terms “glioma” and “miRNA,” we performed the literature search in PubMed, Ovid, and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831553/ https://www.ncbi.nlm.nih.gov/pubmed/25947409 http://dx.doi.org/10.4103/0366-6999.156141 |
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author | Wang, Bao-Cheng Ma, Jie |
author_facet | Wang, Bao-Cheng Ma, Jie |
author_sort | Wang, Bao-Cheng |
collection | PubMed |
description | OBJECTIVE: This overview seeked to bring together the microRNA (miRNA) researches on biogenesis and bio-function in these areas of clinical diagnosis and therapy for malignant glioma. DATA SOURCES: Using the keyword terms “glioma” and “miRNA,” we performed the literature search in PubMed, Ovid, and web.metstr.com databases from their inception to October 2014. STUDY SELECTION: In screening out the quality of the articles, factors such as clinical setting of the study, the size of clinical samples were taken into consideration. Animal studied for verification and reviews article were also included in our data collection. RESULTS: Despite many advance in miRNA for malignant glioma, further studies were still required to focus on the following aspects: (i) Improving the understanding about biogenesis of miRNA and up-down regulation; (ii) utilizing high-throughput miRNA expression analysis to screen out the core miRNA for glioma; (iii) Focusing related miRNAs on the signal transduction pathways that regulate the proliferation and growth of glioma. CONCLUSIONS: We discussed the most promising miRNA, correlative signaling pathway and their relation with gliomas in the way of prompting miRNA target into being a clinical therapeutic strategy. |
format | Online Article Text |
id | pubmed-4831553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48315532016-04-28 Role of MicroRNAs in Malignant Glioma Wang, Bao-Cheng Ma, Jie Chin Med J (Engl) Review Article OBJECTIVE: This overview seeked to bring together the microRNA (miRNA) researches on biogenesis and bio-function in these areas of clinical diagnosis and therapy for malignant glioma. DATA SOURCES: Using the keyword terms “glioma” and “miRNA,” we performed the literature search in PubMed, Ovid, and web.metstr.com databases from their inception to October 2014. STUDY SELECTION: In screening out the quality of the articles, factors such as clinical setting of the study, the size of clinical samples were taken into consideration. Animal studied for verification and reviews article were also included in our data collection. RESULTS: Despite many advance in miRNA for malignant glioma, further studies were still required to focus on the following aspects: (i) Improving the understanding about biogenesis of miRNA and up-down regulation; (ii) utilizing high-throughput miRNA expression analysis to screen out the core miRNA for glioma; (iii) Focusing related miRNAs on the signal transduction pathways that regulate the proliferation and growth of glioma. CONCLUSIONS: We discussed the most promising miRNA, correlative signaling pathway and their relation with gliomas in the way of prompting miRNA target into being a clinical therapeutic strategy. Medknow Publications & Media Pvt Ltd 2015-05-05 /pmc/articles/PMC4831553/ /pubmed/25947409 http://dx.doi.org/10.4103/0366-6999.156141 Text en Copyright: © 2015 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Wang, Bao-Cheng Ma, Jie Role of MicroRNAs in Malignant Glioma |
title | Role of MicroRNAs in Malignant Glioma |
title_full | Role of MicroRNAs in Malignant Glioma |
title_fullStr | Role of MicroRNAs in Malignant Glioma |
title_full_unstemmed | Role of MicroRNAs in Malignant Glioma |
title_short | Role of MicroRNAs in Malignant Glioma |
title_sort | role of micrornas in malignant glioma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831553/ https://www.ncbi.nlm.nih.gov/pubmed/25947409 http://dx.doi.org/10.4103/0366-6999.156141 |
work_keys_str_mv | AT wangbaocheng roleofmicrornasinmalignantglioma AT majie roleofmicrornasinmalignantglioma |