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Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea

Opioids are widely used medicinally as analgesics and abused for hedonic effects, actions that are each complicated by substantial risks such as cardiorespiratory depression. These drugs mimic peptides such as β-endorphin, which has a key role in endogenous analgesia. The β-endorphin in the central...

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Detalles Bibliográficos
Autores principales:	Cerritelli, Serena, Hirschberg, Stefan, Hill, Rob, Balthasar, Nina, Pickering, Anthony E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831707/ https://www.ncbi.nlm.nih.gov/pubmed/27077912 http://dx.doi.org/10.1371/journal.pone.0153187

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