Inhibition of Phosphatase Activity Follows Decline in Sulfatase Activity and Leads to Transcriptional Effects through Sustained Phosphorylation of Transcription Factor MITF

Arylsulfatase B (B-acetylgalactosamine 4-sulfatase; ARSB) is the enzyme that removes 4-sulfate groups from the non-reducing end of the glycosaminoglycans chondroitin 4-sulfate and dermatan sulfate. Decline in ARSB has been shown in malignant prostate, colonic, and mammary cells and tissues, and decl...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Sumit, Feferman, Leo, Tobacman, Joanne K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831796/
https://www.ncbi.nlm.nih.gov/pubmed/27078017
http://dx.doi.org/10.1371/journal.pone.0153463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831796/
https://www.ncbi.nlm.nih.gov/pubmed/27078017
http://dx.doi.org/10.1371/journal.pone.0153463

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