Cargando…

Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India

BACKGROUND: Although melioidosis, is an important disease in many Southeast Asian countries and Australia, there is limited data on its prevalence and disease burden in India. However, an increase in case reports of melioidosis in recent years indicates its endemicity in India. AIMS AND METHODS: A p...

Descripción completa

Detalles Bibliográficos
Autores principales: Vandana, Kalwaje Eshwara, Mukhopadhyay, Chiranjay, Tellapragada, Chaitanya, Kamath, Asha, Tipre, Meghan, Bhat, Vinod, Sathiakumar, Nalini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831803/
https://www.ncbi.nlm.nih.gov/pubmed/27078156
http://dx.doi.org/10.1371/journal.pntd.0004610
_version_ 1782427137641283584
author Vandana, Kalwaje Eshwara
Mukhopadhyay, Chiranjay
Tellapragada, Chaitanya
Kamath, Asha
Tipre, Meghan
Bhat, Vinod
Sathiakumar, Nalini
author_facet Vandana, Kalwaje Eshwara
Mukhopadhyay, Chiranjay
Tellapragada, Chaitanya
Kamath, Asha
Tipre, Meghan
Bhat, Vinod
Sathiakumar, Nalini
author_sort Vandana, Kalwaje Eshwara
collection PubMed
description BACKGROUND: Although melioidosis, is an important disease in many Southeast Asian countries and Australia, there is limited data on its prevalence and disease burden in India. However, an increase in case reports of melioidosis in recent years indicates its endemicity in India. AIMS AND METHODS: A population-based cross-sectional seroprevalence study was undertaken to determine the seroprevalence of B. pseudomallei by indirect haemagglutination assay and to investigate the associated risk determinants. Subjects were 711 adults aged 18 to 65 years residing in Udupi district, located in south-western coast of India. KEY RESULTS: Overall, 29% of the study subjects were seropositive (titer ≥20). Females were twice as likely to be seropositive compared to males. Rates of seroprevalence were similar in farmers and non-farmers. Besides gardening, other factors including socio-demographic, occupational and environmental factors did not show any relationship with seropositive status. MAJOR CONCLUSIONS: There is a serological evidence of exposure to B. pseudomallei among adults in India. While the bacterium inhabits soil, exposure to the agent is not limited to farmers. Non-occupational exposure might play an important role in eliciting antibody response to the bacterium and may also be an important factor in disease causation.
format Online
Article
Text
id pubmed-4831803
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-48318032016-04-22 Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India Vandana, Kalwaje Eshwara Mukhopadhyay, Chiranjay Tellapragada, Chaitanya Kamath, Asha Tipre, Meghan Bhat, Vinod Sathiakumar, Nalini PLoS Negl Trop Dis Research Article BACKGROUND: Although melioidosis, is an important disease in many Southeast Asian countries and Australia, there is limited data on its prevalence and disease burden in India. However, an increase in case reports of melioidosis in recent years indicates its endemicity in India. AIMS AND METHODS: A population-based cross-sectional seroprevalence study was undertaken to determine the seroprevalence of B. pseudomallei by indirect haemagglutination assay and to investigate the associated risk determinants. Subjects were 711 adults aged 18 to 65 years residing in Udupi district, located in south-western coast of India. KEY RESULTS: Overall, 29% of the study subjects were seropositive (titer ≥20). Females were twice as likely to be seropositive compared to males. Rates of seroprevalence were similar in farmers and non-farmers. Besides gardening, other factors including socio-demographic, occupational and environmental factors did not show any relationship with seropositive status. MAJOR CONCLUSIONS: There is a serological evidence of exposure to B. pseudomallei among adults in India. While the bacterium inhabits soil, exposure to the agent is not limited to farmers. Non-occupational exposure might play an important role in eliciting antibody response to the bacterium and may also be an important factor in disease causation. Public Library of Science 2016-04-14 /pmc/articles/PMC4831803/ /pubmed/27078156 http://dx.doi.org/10.1371/journal.pntd.0004610 Text en © 2016 Vandana et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Vandana, Kalwaje Eshwara
Mukhopadhyay, Chiranjay
Tellapragada, Chaitanya
Kamath, Asha
Tipre, Meghan
Bhat, Vinod
Sathiakumar, Nalini
Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India
title Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India
title_full Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India
title_fullStr Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India
title_full_unstemmed Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India
title_short Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India
title_sort seroprevalence of burkholderia pseudomallei among adults in coastal areas in southwestern india
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831803/
https://www.ncbi.nlm.nih.gov/pubmed/27078156
http://dx.doi.org/10.1371/journal.pntd.0004610
work_keys_str_mv AT vandanakalwajeeshwara seroprevalenceofburkholderiapseudomalleiamongadultsincoastalareasinsouthwesternindia
AT mukhopadhyaychiranjay seroprevalenceofburkholderiapseudomalleiamongadultsincoastalareasinsouthwesternindia
AT tellapragadachaitanya seroprevalenceofburkholderiapseudomalleiamongadultsincoastalareasinsouthwesternindia
AT kamathasha seroprevalenceofburkholderiapseudomalleiamongadultsincoastalareasinsouthwesternindia
AT tipremeghan seroprevalenceofburkholderiapseudomalleiamongadultsincoastalareasinsouthwesternindia
AT bhatvinod seroprevalenceofburkholderiapseudomalleiamongadultsincoastalareasinsouthwesternindia
AT sathiakumarnalini seroprevalenceofburkholderiapseudomalleiamongadultsincoastalareasinsouthwesternindia