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Cross-talk between Arg methylation and Ser phosphorylation modulates apoptosis signal–regulating kinase 1 activation in endothelial cells

We describe a novel functional interaction between ASK1 and PRMT5. We show that PRMT5 interacts with and methylates ASK1 at arginine residue 89 and thereby negatively regulates its activity by promoting the interaction between ASK1 and Akt and thus phosphorylating ASK1 at serine residue 83. Furtherm...

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Detalles Bibliográficos
Autores principales:	Chen, Ming, Qu, Xiaosheng, Zhang, Zhiqing, Wu, Huayu, Qin, Xia, Li, Fuji, Liu, Zhenfang, Tian, Liyuan, Miao, Jianhua, Shu, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831888/ https://www.ncbi.nlm.nih.gov/pubmed/26912789 http://dx.doi.org/10.1091/mbc.E15-10-0738

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