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Biological Significance of Mutant Isocitrate Dehydrogenase 1 and 2 in Gliomagenesis
Mutations of the isocitrate dehydrogenase (IDH) genes are considered an important event that occurs at an early stage during gliomagenesis. The mutations often occur in grade 2 or 3 gliomas and secondary glioblastomas. Most IDH mutations are associated with codon 132 and 172 in IDH1 and IDH2 in glio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Japan Neurosurgical Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831942/ https://www.ncbi.nlm.nih.gov/pubmed/26960449 http://dx.doi.org/10.2176/nmc.ra.2015-0322 |