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Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer
PURPOSE: A prospective phase II trial was conducted to evaluate the effectiveness and toxicity of regional hyperthermia and whole liver irradiation (WLI) for numerous chemorefractory liver metastases from colorectal cancer. MATERIALS AND METHODS: Enrolled patients had numerous chemorefractory hepati...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Radiation Oncology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831967/ https://www.ncbi.nlm.nih.gov/pubmed/27104165 http://dx.doi.org/10.3857/roj.2016.34.1.34 |
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author | Yu, Jeong Il Park, Hee Chul Choi, Doo Ho Noh, Jae Myoung Oh, Dongryul Park, Jun Su Chang, Ji Hyun Kim, Seung Tae Lee, Jeeyun Park, Se Hoon Park, Joon Oh Park, Young Suk Lim, Ho Yeong Kang, Won Ki |
author_facet | Yu, Jeong Il Park, Hee Chul Choi, Doo Ho Noh, Jae Myoung Oh, Dongryul Park, Jun Su Chang, Ji Hyun Kim, Seung Tae Lee, Jeeyun Park, Se Hoon Park, Joon Oh Park, Young Suk Lim, Ho Yeong Kang, Won Ki |
author_sort | Yu, Jeong Il |
collection | PubMed |
description | PURPOSE: A prospective phase II trial was conducted to evaluate the effectiveness and toxicity of regional hyperthermia and whole liver irradiation (WLI) for numerous chemorefractory liver metastases from colorectal cancer. MATERIALS AND METHODS: Enrolled patients had numerous chemorefractory hepatic metastases from colorectal cancer. Five sessions of hyperthermia and seven fractions of 3-gray WLI were planned. Health-related quality of life (HRQoL) was determined using the Korean version of the European Organization for Research and Treatment of Cancer quality of life questionnaire C-30 and the Functional Assessment of Cancer Therapy-Hepatobiliary version 4.0. Objective and pain response was evaluated. RESULTS: A total of 12 patients consented to the study and the 10 who received WLI and hyperthermia were analyzed. WLI was completed as planned in nine patients and hyperthermia in eight. Pain response was partial in four patients and stable in four. Partial objective response was achieved in three patients (30.0%) and stable disease was seen in four patients at the 1-month follow-up. One patient died 1 month after treatment because of respiratory failure related to pleural metastasis progression. Other grade III or higher toxicities were detected in three patients; however, all severe toxicities were related to disease progression rather than treatment. No significant difference in HRQoL was noted at the time of assessment for patients who were available for questionnaires. CONCLUSION: Combined WLI and hyperthermia were well tolerated without severe treatment-related toxicity with a promising response from numerous chemorefractory hepatic metastases from colorectal cancer. |
format | Online Article Text |
id | pubmed-4831967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Society for Radiation Oncology |
record_format | MEDLINE/PubMed |
spelling | pubmed-48319672016-04-21 Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer Yu, Jeong Il Park, Hee Chul Choi, Doo Ho Noh, Jae Myoung Oh, Dongryul Park, Jun Su Chang, Ji Hyun Kim, Seung Tae Lee, Jeeyun Park, Se Hoon Park, Joon Oh Park, Young Suk Lim, Ho Yeong Kang, Won Ki Radiat Oncol J Original Article PURPOSE: A prospective phase II trial was conducted to evaluate the effectiveness and toxicity of regional hyperthermia and whole liver irradiation (WLI) for numerous chemorefractory liver metastases from colorectal cancer. MATERIALS AND METHODS: Enrolled patients had numerous chemorefractory hepatic metastases from colorectal cancer. Five sessions of hyperthermia and seven fractions of 3-gray WLI were planned. Health-related quality of life (HRQoL) was determined using the Korean version of the European Organization for Research and Treatment of Cancer quality of life questionnaire C-30 and the Functional Assessment of Cancer Therapy-Hepatobiliary version 4.0. Objective and pain response was evaluated. RESULTS: A total of 12 patients consented to the study and the 10 who received WLI and hyperthermia were analyzed. WLI was completed as planned in nine patients and hyperthermia in eight. Pain response was partial in four patients and stable in four. Partial objective response was achieved in three patients (30.0%) and stable disease was seen in four patients at the 1-month follow-up. One patient died 1 month after treatment because of respiratory failure related to pleural metastasis progression. Other grade III or higher toxicities were detected in three patients; however, all severe toxicities were related to disease progression rather than treatment. No significant difference in HRQoL was noted at the time of assessment for patients who were available for questionnaires. CONCLUSION: Combined WLI and hyperthermia were well tolerated without severe treatment-related toxicity with a promising response from numerous chemorefractory hepatic metastases from colorectal cancer. The Korean Society for Radiation Oncology 2016-03 2016-03-30 /pmc/articles/PMC4831967/ /pubmed/27104165 http://dx.doi.org/10.3857/roj.2016.34.1.34 Text en Copyright © 2016. The Korean Society for Radiation Oncology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yu, Jeong Il Park, Hee Chul Choi, Doo Ho Noh, Jae Myoung Oh, Dongryul Park, Jun Su Chang, Ji Hyun Kim, Seung Tae Lee, Jeeyun Park, Se Hoon Park, Joon Oh Park, Young Suk Lim, Ho Yeong Kang, Won Ki Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer |
title | Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer |
title_full | Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer |
title_fullStr | Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer |
title_full_unstemmed | Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer |
title_short | Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer |
title_sort | prospective phase ii trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831967/ https://www.ncbi.nlm.nih.gov/pubmed/27104165 http://dx.doi.org/10.3857/roj.2016.34.1.34 |
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