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Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation

The neurochemical underpinnings of sleep's contribution to the establishment and maintenance of memory traces are largely unexplored. Considering that intranasal insulin administration to the CNS improves memory functions in healthy and memory-impaired humans, we tested whether brain insulin si...

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Autores principales: Feld, Gordon B, Wilhem, Ines, Benedict, Christian, Rüdel, Benjamin, Klameth, Corinna, Born, Jan, Hallschmid, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832015/
https://www.ncbi.nlm.nih.gov/pubmed/26448203
http://dx.doi.org/10.1038/npp.2015.312
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author Feld, Gordon B
Wilhem, Ines
Benedict, Christian
Rüdel, Benjamin
Klameth, Corinna
Born, Jan
Hallschmid, Manfred
author_facet Feld, Gordon B
Wilhem, Ines
Benedict, Christian
Rüdel, Benjamin
Klameth, Corinna
Born, Jan
Hallschmid, Manfred
author_sort Feld, Gordon B
collection PubMed
description The neurochemical underpinnings of sleep's contribution to the establishment and maintenance of memory traces are largely unexplored. Considering that intranasal insulin administration to the CNS improves memory functions in healthy and memory-impaired humans, we tested whether brain insulin signaling and sleep interact to enhance memory consolidation in healthy participants. We investigated the effect of intranasal insulin on sleep-associated neurophysiological and neuroendocrine parameters and memory consolidation in 16 men and 16 women (aged 18–30 years), who learned a declarative word-pair task and a procedural finger sequence tapping task in the evening before intranasal insulin (160 IU) or placebo administration and 8 h of nocturnal sleep. On the subsequent evening, they learned interfering word-pairs and a new finger sequence before retrieving the original memories. Insulin increased growth hormone concentrations in the first night-half and EEG delta power during the second 90 min of non-rapid-eye-movement sleep. Insulin treatment impaired the acquisition of new contents in both the declarative and procedural memory systems on the next day, whereas retrieval of original memories was unchanged. Results indicate that sleep-associated memory consolidation is not a primary mediator of insulin's acute memory-improving effect, but that the peptide acts on mechanisms that diminish the subsequent encoding of novel information. Thus, by inhibiting processes of active forgetting during sleep, central nervous insulin might reduce the interfering influence of encoding new information.
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spelling pubmed-48320152016-05-01 Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation Feld, Gordon B Wilhem, Ines Benedict, Christian Rüdel, Benjamin Klameth, Corinna Born, Jan Hallschmid, Manfred Neuropsychopharmacology Original Article The neurochemical underpinnings of sleep's contribution to the establishment and maintenance of memory traces are largely unexplored. Considering that intranasal insulin administration to the CNS improves memory functions in healthy and memory-impaired humans, we tested whether brain insulin signaling and sleep interact to enhance memory consolidation in healthy participants. We investigated the effect of intranasal insulin on sleep-associated neurophysiological and neuroendocrine parameters and memory consolidation in 16 men and 16 women (aged 18–30 years), who learned a declarative word-pair task and a procedural finger sequence tapping task in the evening before intranasal insulin (160 IU) or placebo administration and 8 h of nocturnal sleep. On the subsequent evening, they learned interfering word-pairs and a new finger sequence before retrieving the original memories. Insulin increased growth hormone concentrations in the first night-half and EEG delta power during the second 90 min of non-rapid-eye-movement sleep. Insulin treatment impaired the acquisition of new contents in both the declarative and procedural memory systems on the next day, whereas retrieval of original memories was unchanged. Results indicate that sleep-associated memory consolidation is not a primary mediator of insulin's acute memory-improving effect, but that the peptide acts on mechanisms that diminish the subsequent encoding of novel information. Thus, by inhibiting processes of active forgetting during sleep, central nervous insulin might reduce the interfering influence of encoding new information. Nature Publishing Group 2016-05 2015-11-04 /pmc/articles/PMC4832015/ /pubmed/26448203 http://dx.doi.org/10.1038/npp.2015.312 Text en Copyright © 2016 American College of Neuropsychopharmacology http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Original Article
Feld, Gordon B
Wilhem, Ines
Benedict, Christian
Rüdel, Benjamin
Klameth, Corinna
Born, Jan
Hallschmid, Manfred
Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation
title Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation
title_full Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation
title_fullStr Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation
title_full_unstemmed Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation
title_short Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation
title_sort central nervous insulin signaling in sleep-associated memory formation and neuroendocrine regulation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832015/
https://www.ncbi.nlm.nih.gov/pubmed/26448203
http://dx.doi.org/10.1038/npp.2015.312
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