Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells

MALT1 channels proximal T-cell receptor (TCR) signalling to downstream signalling pathways. With MALT1A and MALT1B two conserved splice variants exist and we demonstrate here that MALT1 alternative splicing supports optimal T-cell activation. Inclusion of exon7 in MALT1A facilitates the recruitment...

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Detalles Bibliográficos
Autores principales: Meininger, Isabel, Griesbach, Richard A., Hu, Desheng, Gehring, Torben, Seeholzer, Thomas, Bertossi, Arianna, Kranich, Jan, Oeckinghaus, Andrea, Eitelhuber, Andrea C., Greczmiel, Ute, Gewies, Andreas, Schmidt-Supprian, Marc, Ruland, Jürgen, Brocker, Thomas, Heissmeyer, Vigo, Heyd, Florian, Krappmann, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832065/
https://www.ncbi.nlm.nih.gov/pubmed/27068814
http://dx.doi.org/10.1038/ncomms11292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832065/
https://www.ncbi.nlm.nih.gov/pubmed/27068814
http://dx.doi.org/10.1038/ncomms11292

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