BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia

Bruton's tyrosine kinase (BTK) is involved in the regulation of B-cell growth, migration and adhesion. The importance of BTK in cell trafficking is emphasized by the clonal contraction proceeded by lymphocytosis typical for the enzyme inhibitor, ibrutinib, in B-cell malignancies, including chro...

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Detalles Bibliográficos
Autores principales: Chen, S-S, Chang, B Y, Chang, S, Tong, T, Ham, S, Sherry, B, Burger, J A, Rai, K R, Chiorazzi, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832074/
https://www.ncbi.nlm.nih.gov/pubmed/26582643
http://dx.doi.org/10.1038/leu.2015.316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832074/
https://www.ncbi.nlm.nih.gov/pubmed/26582643
http://dx.doi.org/10.1038/leu.2015.316

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