Cargando…

BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia

Bruton's tyrosine kinase (BTK) is involved in the regulation of B-cell growth, migration and adhesion. The importance of BTK in cell trafficking is emphasized by the clonal contraction proceeded by lymphocytosis typical for the enzyme inhibitor, ibrutinib, in B-cell malignancies, including chro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, S-S, Chang, B Y, Chang, S, Tong, T, Ham, S, Sherry, B, Burger, J A, Rai, K R, Chiorazzi, N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832074/ https://www.ncbi.nlm.nih.gov/pubmed/26582643 http://dx.doi.org/10.1038/leu.2015.316

Ejemplares similares

BTK Inhibition Impairs the Innate Response Against Fungal Infection in Patients With Chronic Lymphocytic Leukemia
por: Fiorcari, Stefania, et al.
Publicado: (2020)

BTK mutations in patients with chronic lymphocytic leukemia receiving tirabrutinib
por: Jackson, Ross A., et al.
Publicado: (2023)

The Role of BTK Inhibition in the Treatment of Chronic Lymphocytic Leukemia: A Clinical View
por: Tambaro, Francesco Paolo, et al.
Publicado: (2021)

PB1912: BTK AND PLCG2 GENE MUTATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS WITH RESISTANCE TO COVALENT BTK INHIBITOR
por: Likold, Ekaterina, et al.
Publicado: (2023)

BTK Inhibitors in Chronic Lymphocytic Leukemia: Biological Activity and Immune Effects
por: Palma, Marzia, et al.
Publicado: (2021)

Cell lines generated from a chronic lymphocytic leukemia mouse model exhibit constitutive Btk and Akt signaling
por: Singh, Simar Pal, et al.
Publicado: (2017)

Impaired B Cell Apoptosis Results in Autoimmunity That Is Alleviated by Ablation of Btk
por: Wright, Jacqueline A., et al.
Publicado: (2021)

Use of BTK Inhibitors in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): A Practical Guidance
por: St-Pierre, Frédérique, et al.
Publicado: (2022)

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition
por: Burger, Jan A., et al.
Publicado: (2016)

Identification and characterization of distinct IL-17F expression patterns and signaling pathways in chronic lymphocytic leukemia and normal B lymphocytes
por: Sherry, Barbara, et al.
Publicado: (2015)

Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking
por: Joseph, Prem Raj B., et al.
Publicado: (2017)

Differences in Sulfotyrosine Binding amongst CXCR1 and CXCR2 Chemokine Ligands
por: Moussouras, Natasha A., et al.
Publicado: (2017)

Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib
por: Guo, Ailin, et al.
Publicado: (2015)

Combining BTK inhibitors with BCL2 inhibitors for treating chronic lymphocytic leukemia and mantle cell lymphoma
por: Zhang, Jing, et al.
Publicado: (2022)

Cardiovascular Toxicities of BTK Inhibitors in Chronic Lymphocytic Leukemia: JACC: CardioOncology State-of-the-Art Review
por: Quartermaine, Cooper, et al.
Publicado: (2023)

Expression and functional roles of the chemokine receptor CXCR7 in acute myeloid leukemia cells
por: Kim, Ha-Yon, et al.
Publicado: (2015)

Agonists for the Chemokine Receptor CXCR4
por: Lefrançois, Marilou, et al.
Publicado: (2011)

From identification of the BTK kinase to effective management of leukemia
por: Smith, C I E
Publicado: (2017)

Specific Receptors for the Chemokines CXCR2 and CXCR4 in Pancreatic Cancer
por: Litman-Zawadzka, Ala, et al.
Publicado: (2020)

Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes
por: Nojima, Hiroyuki, et al.
Publicado: (2016)

AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression
por: Oppezzo, Pablo, et al.
Publicado: (2021)

Chemokine Receptors CXCR4 and CXCR7 are Associated with Tumor Aggressiveness and Prognosis in Extramammary Paget Disease
por: Chang, Kun, et al.
Publicado: (2017)

Structure of the Chemokine Receptor CXCR1 in Phospholipid Bilayers
por: Park, Sang Ho, et al.
Publicado: (2012)

BTK Inhibitors Impair Platelet-Mediated Antifungal Activity
por: Nasillo, Vincenzo, et al.
Publicado: (2022)

Treatment of relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma with the BTK inhibitor zanubrutinib: phase 2, single-arm, multicenter study
por: Xu, Wei, et al.
Publicado: (2020)

The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer
por: Shi, Yi, et al.
Publicado: (2020)

Population Pharmacokinetics and Exposure Response Assessment of CC‐292, a Potent BTK Inhibitor, in Patients With Chronic Lymphocytic Leukemia
por: Li, Yan, et al.
Publicado: (2017)

Managing chronic lymphocytic leukemia in 2020: an update on recent clinical advances with a focus on BTK and BCL-2 inhibitors
por: Bose, Prithviraj, et al.
Publicado: (2021)

Overcoming of Microenvironment Protection on Primary Chronic Lymphocytic Leukemia Cells after Treatment with BTK and MDM2 Pharmacological Inhibitors
por: Rimondi, Erika, et al.
Publicado: (2021)

Regulation of the Chemokine Receptor CXCR4 by Hypoxia
por: Schioppa, Tiziana, et al.
Publicado: (2003)

Molecular Imaging of Chemokine Receptor CXCR4
por: Weiss, Ido. D., et al.
Publicado: (2013)

The Structure of a CXCR4:Chemokine Complex
por: Handel, Tracy Marie
Publicado: (2015)

FcγRIIb-BCR coligation inhibits B-cell receptor signaling in chronic lymphocytic leukemia
por: Bosch, Rosa, et al.
Publicado: (2020)

Computer‐aided assessment of the chemokine receptors CXCR3, CXCR4 and CXCR7 expression in gallbladder carcinoma
por: Yu, Xiao, et al.
Publicado: (2020)

Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK
por: Kueffer, Lauren E., et al.
Publicado: (2021)

Acquired BTK mutations associated with resistance to noncovalent BTK inhibitors
por: Qi, Jialei, et al.
Publicado: (2023)

Impact of the Chemokine Receptors CXCR4 and CXCR7 on Clinical Outcome in Adrenocortical Carcinoma
por: Chifu, Irina, et al.
Publicado: (2020)

Chemokines and Chemokine Receptors in Lymphocyte Traffic
por: Loetsacher, Pius
Publicado: (2000)

Chemokine receptors in the rheumatoid synovium: upregulation of CXCR5
por: Schmutz, Caroline, et al.
Publicado: (2005)

Boosting chemokine receptor recycling: an elixir of life for chronic lymphocytic leukemia
por: Patrussi, Laura, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ngnjlodouoj3noovcmfpso314l