Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance

p53 is a central mediator of cellular stress responses, and its precise regulation is essential for the normal progression of hematopoiesis. MYSM1 is an epigenetic regulator essential for the maintenance of hematopoietic stem cell (HSC) function, hematopoietic progenitor survival, and lymphocyte dev...

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Detalles Bibliográficos
Autores principales: Belle, J I, Petrov, J C, Langlais, D, Robert, F, Cencic, R, Shen, S, Pelletier, J, Gros, P, Nijnik, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832099/
https://www.ncbi.nlm.nih.gov/pubmed/26768662
http://dx.doi.org/10.1038/cdd.2015.140

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