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Cutaneous presentation of Double Hit Lymphoma: A Case Report With Review of the Literature

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), representing approximately 25% of diagnosed NHL. DLBCL is heterogeneous disease both clinically and genetically. The 3 most common chromosomal translocations in DLBCL involve the oncogenes BCL2, BCL6, and MY...

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Autores principales: Khelfa, Yousef, Lebowicz, Yehuda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832138/
https://www.ncbi.nlm.nih.gov/pubmed/27115017
http://dx.doi.org/10.1177/2324709616642592
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author Khelfa, Yousef
Lebowicz, Yehuda
author_facet Khelfa, Yousef
Lebowicz, Yehuda
author_sort Khelfa, Yousef
collection PubMed
description Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), representing approximately 25% of diagnosed NHL. DLBCL is heterogeneous disease both clinically and genetically. The 3 most common chromosomal translocations in DLBCL involve the oncogenes BCL2, BCL6, and MYC. Double hit (DH) DLBCL is an aggressive form in which MYC rearrangement is associated with either BCL2 or BCL6 rearrangement. Patients typically present with a rapidly growing mass, often with B symptoms. Extranodal disease is often present. Though there is a paucity of prospective trials in this subtype, double hit lymphoma (DHL) has been linked to very poor outcomes when patients are treated with standard R-CHOP. There is, therefore, a lack of consensus regarding the standard treatment for DHL. Several retrospective analyses have been conducted to help guide treatment of this disease. These suggest that DA EPOCH-R may be the most promising regimen and that achievement of complete resolution predicts better long-term outcomes.
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spelling pubmed-48321382016-04-25 Cutaneous presentation of Double Hit Lymphoma: A Case Report With Review of the Literature Khelfa, Yousef Lebowicz, Yehuda J Investig Med High Impact Case Rep Case Report Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), representing approximately 25% of diagnosed NHL. DLBCL is heterogeneous disease both clinically and genetically. The 3 most common chromosomal translocations in DLBCL involve the oncogenes BCL2, BCL6, and MYC. Double hit (DH) DLBCL is an aggressive form in which MYC rearrangement is associated with either BCL2 or BCL6 rearrangement. Patients typically present with a rapidly growing mass, often with B symptoms. Extranodal disease is often present. Though there is a paucity of prospective trials in this subtype, double hit lymphoma (DHL) has been linked to very poor outcomes when patients are treated with standard R-CHOP. There is, therefore, a lack of consensus regarding the standard treatment for DHL. Several retrospective analyses have been conducted to help guide treatment of this disease. These suggest that DA EPOCH-R may be the most promising regimen and that achievement of complete resolution predicts better long-term outcomes. SAGE Publications 2016-04-08 /pmc/articles/PMC4832138/ /pubmed/27115017 http://dx.doi.org/10.1177/2324709616642592 Text en © 2016 American Federation for Medical Research http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Khelfa, Yousef
Lebowicz, Yehuda
Cutaneous presentation of Double Hit Lymphoma: A Case Report With Review of the Literature
title Cutaneous presentation of Double Hit Lymphoma: A Case Report With Review of the Literature
title_full Cutaneous presentation of Double Hit Lymphoma: A Case Report With Review of the Literature
title_fullStr Cutaneous presentation of Double Hit Lymphoma: A Case Report With Review of the Literature
title_full_unstemmed Cutaneous presentation of Double Hit Lymphoma: A Case Report With Review of the Literature
title_short Cutaneous presentation of Double Hit Lymphoma: A Case Report With Review of the Literature
title_sort cutaneous presentation of double hit lymphoma: a case report with review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832138/
https://www.ncbi.nlm.nih.gov/pubmed/27115017
http://dx.doi.org/10.1177/2324709616642592
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