Sphingosine 1-phosphate receptor 2 (S1P(2)) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy

Ototoxic drugs, such as platinum-based chemotherapeutics, often lead to permanent hearing loss through apoptosis of neuroepithelial hair cells and afferent neurons of the cochlea. There is no approved therapy for preventing or reversing this process. Our previous studies identified a G protein-coupl...

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Detalles Bibliográficos
Autores principales: Herr, Deron R., Reolo, Marie J. Y., Peh, Yee Xin, Wang, Wei, Lee, Chang-Wook, Rivera, Rich, Paterson, Ian C., Chun, Jerold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832229/
https://www.ncbi.nlm.nih.gov/pubmed/27080739
http://dx.doi.org/10.1038/srep24541

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