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Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in cancer angiogenesis. In this study, a series of novel furo[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine based-derivatives were designed and synthesized as VEGFR-2 inhibitors, in accordance to the structure activity relat...
Autores principales: | Aziz, Marwa A., Serya, Rabah A. T., Lasheen, Deena S., Abdel-Aziz, Amal Kamal, Esmat, Ahmed, Mansour, Ahmed M., Singab, Abdel Nasser B., Abouzid, Khaled A. M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832243/ https://www.ncbi.nlm.nih.gov/pubmed/27080011 http://dx.doi.org/10.1038/srep24460 |
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