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Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in cancer angiogenesis. In this study, a series of novel furo[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine based-derivatives were designed and synthesized as VEGFR-2 inhibitors, in accordance to the structure activity relat...

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Detalles Bibliográficos
Autores principales:	Aziz, Marwa A., Serya, Rabah A. T., Lasheen, Deena S., Abdel-Aziz, Amal Kamal, Esmat, Ahmed, Mansour, Ahmed M., Singab, Abdel Nasser B., Abouzid, Khaled A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832243/ https://www.ncbi.nlm.nih.gov/pubmed/27080011 http://dx.doi.org/10.1038/srep24460

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