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High Serum SHBG Predicts Incident Vertebral Fractures in Elderly Men
Previous prospective cohort studies have shown that serum levels of sex steroids and sex hormone‐binding globulin (SHBG) associate with nonvertebral fracture risk in men. The predictive value of sex hormones and SHBG for vertebral fracture risk specifically is, however, less studied. Elderly men (ag...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832265/ https://www.ncbi.nlm.nih.gov/pubmed/26391196 http://dx.doi.org/10.1002/jbmr.2718 |
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author | Vandenput, Liesbeth Mellström, Dan Kindmark, Andreas Johansson, Helena Lorentzon, Mattias Leung, Jason Redlund‐Johnell, Inga Rosengren, Björn E Karlsson, Magnus K Wang, Yi‐Xiang Kwok, Timothy Ohlsson, Claes |
author_facet | Vandenput, Liesbeth Mellström, Dan Kindmark, Andreas Johansson, Helena Lorentzon, Mattias Leung, Jason Redlund‐Johnell, Inga Rosengren, Björn E Karlsson, Magnus K Wang, Yi‐Xiang Kwok, Timothy Ohlsson, Claes |
author_sort | Vandenput, Liesbeth |
collection | PubMed |
description | Previous prospective cohort studies have shown that serum levels of sex steroids and sex hormone‐binding globulin (SHBG) associate with nonvertebral fracture risk in men. The predictive value of sex hormones and SHBG for vertebral fracture risk specifically is, however, less studied. Elderly men (aged ≥65 years) from Sweden and Hong Kong participating in the Osteoporotic Fractures in Men (MrOS) study had baseline estradiol and testosterone analyzed by gas chromatography–mass spectrometry (GC‐MS) and SHBG by immunoradiometric assay (IRMA). Incident clinical vertebral fractures (n = 242 cases) were evaluated in 4324 men during an average follow‐up of 9.1 years. In a subsample of these men (n = 2256), spine X‐rays were obtained at baseline and after an average follow‐up of 4.3 years to identify incident radiographic vertebral fractures (n = 157 cases). The likelihood of incident clinical and radiographic vertebral fractures was estimated by Cox proportional hazards models and logistic regression models, respectively. Neither serum estradiol (hazard ratio [HR] per SD increase = 0.93, 95% confidence interval [CI] 0.80–1.08) nor testosterone (1.05, 0.91–1.21) predicted incident clinical vertebral fractures in age‐adjusted models in the combined data set. High serum SHBG, however, associated with increased clinical vertebral fracture risk (1.24, 1.12–1.37). This association remained significant after further adjustment for FRAX with or without bone mineral density (BMD). SHBG also associated with increased incident radiographic vertebral fracture risk (combined data set; odds ratio [OR] per SD increase = 1.23, 95% CI 1.05–1.44). This association remained significant after adjustment for FRAX with or without BMD. In conclusion, high SHBG predicts incident clinical and radiographic vertebral fractures in elderly men and adds moderate information beyond FRAX with BMD for vertebral fracture risk prediction. © 2015 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research. |
format | Online Article Text |
id | pubmed-4832265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48322652016-04-20 High Serum SHBG Predicts Incident Vertebral Fractures in Elderly Men Vandenput, Liesbeth Mellström, Dan Kindmark, Andreas Johansson, Helena Lorentzon, Mattias Leung, Jason Redlund‐Johnell, Inga Rosengren, Björn E Karlsson, Magnus K Wang, Yi‐Xiang Kwok, Timothy Ohlsson, Claes J Bone Miner Res Original Articles Previous prospective cohort studies have shown that serum levels of sex steroids and sex hormone‐binding globulin (SHBG) associate with nonvertebral fracture risk in men. The predictive value of sex hormones and SHBG for vertebral fracture risk specifically is, however, less studied. Elderly men (aged ≥65 years) from Sweden and Hong Kong participating in the Osteoporotic Fractures in Men (MrOS) study had baseline estradiol and testosterone analyzed by gas chromatography–mass spectrometry (GC‐MS) and SHBG by immunoradiometric assay (IRMA). Incident clinical vertebral fractures (n = 242 cases) were evaluated in 4324 men during an average follow‐up of 9.1 years. In a subsample of these men (n = 2256), spine X‐rays were obtained at baseline and after an average follow‐up of 4.3 years to identify incident radiographic vertebral fractures (n = 157 cases). The likelihood of incident clinical and radiographic vertebral fractures was estimated by Cox proportional hazards models and logistic regression models, respectively. Neither serum estradiol (hazard ratio [HR] per SD increase = 0.93, 95% confidence interval [CI] 0.80–1.08) nor testosterone (1.05, 0.91–1.21) predicted incident clinical vertebral fractures in age‐adjusted models in the combined data set. High serum SHBG, however, associated with increased clinical vertebral fracture risk (1.24, 1.12–1.37). This association remained significant after further adjustment for FRAX with or without bone mineral density (BMD). SHBG also associated with increased incident radiographic vertebral fracture risk (combined data set; odds ratio [OR] per SD increase = 1.23, 95% CI 1.05–1.44). This association remained significant after adjustment for FRAX with or without BMD. In conclusion, high SHBG predicts incident clinical and radiographic vertebral fractures in elderly men and adds moderate information beyond FRAX with BMD for vertebral fracture risk prediction. © 2015 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research. John Wiley and Sons Inc. 2016-01-20 2016-03 /pmc/articles/PMC4832265/ /pubmed/26391196 http://dx.doi.org/10.1002/jbmr.2718 Text en © 2015 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Vandenput, Liesbeth Mellström, Dan Kindmark, Andreas Johansson, Helena Lorentzon, Mattias Leung, Jason Redlund‐Johnell, Inga Rosengren, Björn E Karlsson, Magnus K Wang, Yi‐Xiang Kwok, Timothy Ohlsson, Claes High Serum SHBG Predicts Incident Vertebral Fractures in Elderly Men |
title | High Serum SHBG Predicts Incident Vertebral Fractures in Elderly Men |
title_full | High Serum SHBG Predicts Incident Vertebral Fractures in Elderly Men |
title_fullStr | High Serum SHBG Predicts Incident Vertebral Fractures in Elderly Men |
title_full_unstemmed | High Serum SHBG Predicts Incident Vertebral Fractures in Elderly Men |
title_short | High Serum SHBG Predicts Incident Vertebral Fractures in Elderly Men |
title_sort | high serum shbg predicts incident vertebral fractures in elderly men |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832265/ https://www.ncbi.nlm.nih.gov/pubmed/26391196 http://dx.doi.org/10.1002/jbmr.2718 |
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