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Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11
The ability of proteins to bind and interact with protein partners plays fundamental roles in many cellular contexts. X‐ray crystallography has been a powerful approach to understand protein‐protein interactions; however, a challenge in the crystallization of proteins and their complexes is the pres...
Autores principales: | Fowler, Melissa L., McPhail, Jacob A., Jenkins, Meredith L., Masson, Glenn R., Rutaganira, Florentine U., Shokat, Kevan M., Williams, Roger L., Burke, John E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832280/ https://www.ncbi.nlm.nih.gov/pubmed/26756197 http://dx.doi.org/10.1002/pro.2879 |
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