Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid

OBJECTIVE: In the majority of patients with rheumatoid arthritis (RA), antibodies specifically recognize citrullinated autoantigens that are generated by peptidylarginine deiminases (PADs). Neutrophils express high levels of PAD and accumulate in the synovial fluid (SF) of RA patients during disease...

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Detalles Bibliográficos
Autores principales: Spengler, Julia, Lugonja, Božo, Jimmy Ytterberg, A., Zubarev, Roman A., Creese, Andrew J., Pearson, Mark J., Grant, Melissa M., Milward, Michael, Lundberg, Karin, Buckley, Christopher D., Filer, Andrew, Raza, Karim, Cooper, Paul R., Chapple, Iain L., Scheel‐Toellner, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Rheumatoid Arthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832324/
https://www.ncbi.nlm.nih.gov/pubmed/26245941
http://dx.doi.org/10.1002/art.39313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832324/
https://www.ncbi.nlm.nih.gov/pubmed/26245941
http://dx.doi.org/10.1002/art.39313

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