The innate immune response in human tuberculosis

M ycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system before the initiation of an adaptive immune response. This innate protection requires a variety of robust cell autonomous responses from many different host immune cell types. However, Mtb has evolved strategies t...

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Detalles Bibliográficos
Autores principales: Lerner, Thomas R., Borel, Sophie, Gutierrez, Maximiliano G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Microreviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832344/
https://www.ncbi.nlm.nih.gov/pubmed/26135005
http://dx.doi.org/10.1111/cmi.12480
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author Lerner, Thomas R.
Borel, Sophie
Gutierrez, Maximiliano G.
author_facet Lerner, Thomas R.
Borel, Sophie
Gutierrez, Maximiliano G.
author_sort Lerner, Thomas R.
collection PubMed
description M ycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system before the initiation of an adaptive immune response. This innate protection requires a variety of robust cell autonomous responses from many different host immune cell types. However, Mtb has evolved strategies to circumvent some of these defences. In this mini‐review, we discuss these host–pathogen interactions with a focus on studies performed in human cells and/or supported by human genetics studies (such as genome‐wide association studies).
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spelling pubmed-48323442016-04-20 The innate immune response in human tuberculosis Lerner, Thomas R. Borel, Sophie Gutierrez, Maximiliano G. Cell Microbiol Microreviews M ycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system before the initiation of an adaptive immune response. This innate protection requires a variety of robust cell autonomous responses from many different host immune cell types. However, Mtb has evolved strategies to circumvent some of these defences. In this mini‐review, we discuss these host–pathogen interactions with a focus on studies performed in human cells and/or supported by human genetics studies (such as genome‐wide association studies). John Wiley and Sons Inc. 2015-07-28 2015-09 /pmc/articles/PMC4832344/ /pubmed/26135005 http://dx.doi.org/10.1111/cmi.12480 Text en © 2015 The Authors. Cellular Microbiology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Microreviews
Lerner, Thomas R.
Borel, Sophie
Gutierrez, Maximiliano G.
The innate immune response in human tuberculosis
title The innate immune response in human tuberculosis
title_full The innate immune response in human tuberculosis
title_fullStr The innate immune response in human tuberculosis
title_full_unstemmed The innate immune response in human tuberculosis
title_short The innate immune response in human tuberculosis
title_sort innate immune response in human tuberculosis
topic Microreviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832344/
https://www.ncbi.nlm.nih.gov/pubmed/26135005
http://dx.doi.org/10.1111/cmi.12480
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