NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas

Small cell lung cancers (SCLCs) and extrapulmonary small cell cancers (SCCs) are very aggressive tumors arising de novo as primary small cell cancer with characteristic genetic lesions in RB1 and TP53. Based on murine models, neuroendocrine stem cells of the terminal bronchioli have been postulated...

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Detalles Bibliográficos
Autores principales: Meder, Lydia, König, Katharina, Ozretić, Luka, Schultheis, Anne M., Ueckeroth, Frank, Ade, Carsten P., Albus, Kerstin, Boehm, Diana, Rommerscheidt‐Fuss, Ursula, Florin, Alexandra, Buhl, Theresa, Hartmann, Wolfgang, Wolf, Jürgen, Merkelbach‐Bruse, Sabine, Eilers, Martin, Perner, Sven, Heukamp, Lukas C., Buettner, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Molecular Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832386/
https://www.ncbi.nlm.nih.gov/pubmed/26340530
http://dx.doi.org/10.1002/ijc.29835

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