Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene‐Containing [2]Rotaxane Scaffold

A synthetic approach combining recent concepts for the preparation of multifunctional nanomolecules (click chemistry on multifunctional scaffolds) with supramolecular chemistry (self‐assembly to prepare rotaxanes) gave easy access to a large variety of sophisticated [2]rotaxane heteroglycoclusters....

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Detalles Bibliográficos
Autores principales: Vincent, Stéphane P., Buffet, Kevin, Nierengarten, Iwona, Imberty, Anne, Nierengarten, Jean‐François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832831/
https://www.ncbi.nlm.nih.gov/pubmed/26467313
http://dx.doi.org/10.1002/chem.201504110
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author Vincent, Stéphane P.
Buffet, Kevin
Nierengarten, Iwona
Imberty, Anne
Nierengarten, Jean‐François
author_facet Vincent, Stéphane P.
Buffet, Kevin
Nierengarten, Iwona
Imberty, Anne
Nierengarten, Jean‐François
author_sort Vincent, Stéphane P.
collection PubMed
description A synthetic approach combining recent concepts for the preparation of multifunctional nanomolecules (click chemistry on multifunctional scaffolds) with supramolecular chemistry (self‐assembly to prepare rotaxanes) gave easy access to a large variety of sophisticated [2]rotaxane heteroglycoclusters. Specifically, compounds combining galactose and fucose have been prepared to target the two bacterial lectins (LecA and LecB) from the opportunistic pathogen Pseudomonas aeruginosa.
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spelling pubmed-48328312016-04-27 Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene‐Containing [2]Rotaxane Scaffold Vincent, Stéphane P. Buffet, Kevin Nierengarten, Iwona Imberty, Anne Nierengarten, Jean‐François Chemistry Communications A synthetic approach combining recent concepts for the preparation of multifunctional nanomolecules (click chemistry on multifunctional scaffolds) with supramolecular chemistry (self‐assembly to prepare rotaxanes) gave easy access to a large variety of sophisticated [2]rotaxane heteroglycoclusters. Specifically, compounds combining galactose and fucose have been prepared to target the two bacterial lectins (LecA and LecB) from the opportunistic pathogen Pseudomonas aeruginosa. WILEY‐VCH Verlag 2015-11-03 2016-01-04 /pmc/articles/PMC4832831/ /pubmed/26467313 http://dx.doi.org/10.1002/chem.201504110 Text en © 2015 The Authors. Published by Wiley‐VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of Creative Commons Attribution NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. Open access.
spellingShingle Communications
Vincent, Stéphane P.
Buffet, Kevin
Nierengarten, Iwona
Imberty, Anne
Nierengarten, Jean‐François
Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene‐Containing [2]Rotaxane Scaffold
title Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene‐Containing [2]Rotaxane Scaffold
title_full Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene‐Containing [2]Rotaxane Scaffold
title_fullStr Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene‐Containing [2]Rotaxane Scaffold
title_full_unstemmed Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene‐Containing [2]Rotaxane Scaffold
title_short Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene‐Containing [2]Rotaxane Scaffold
title_sort biologically active heteroglycoclusters constructed on a pillar[5]arene‐containing [2]rotaxane scaffold
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832831/
https://www.ncbi.nlm.nih.gov/pubmed/26467313
http://dx.doi.org/10.1002/chem.201504110
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