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C—H Oxidation of Ingenanes Enables Potent and Selective Protein Kinase C Isoform Activation

Ingenol derivatives with varying degrees of oxidation were prepared by two‐phase terpene synthesis. This strategy has allowed access to analogues that cannot be prepared by semisynthesis from natural ingenol. Complex ingenanes resulting from divergent C—H oxidation of a common intermediate were foun...

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Detalles Bibliográficos
Autores principales:	Jin, Yehua, Yeh, Chien‐Hung, Kuttruff, Christian A., Jørgensen, Lars, Dünstl, Georg, Felding, Jakob, Natarajan, Swaminathan R., Baran, Phil S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY‐VCH Verlag 2015
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832842/ https://www.ncbi.nlm.nih.gov/pubmed/26418078 http://dx.doi.org/10.1002/anie.201507977

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