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Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy: A Multi-center Randomized Control Study

BACKGROUND: Helicobacter pylori (H. pylori) frequently colonizes the stomach. Gastroesophageal reflux disease (GERD) is a common and costly disease. But the relationship of H. pylori and GERD is still unclear. This study aimed to explore the effect of H. pylori and its eradication on reflux esophagi...

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Autores principales: Xue, Yan, Zhou, Li-Ya, Lin, San-Ren, Hou, Xiao-Hua, Li, Zhao-Shen, Chen, Min-Hu, Yan, Xiu-E, Meng, Ling-Mei, Zhang, Jing, Lu, Jing-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832960/
https://www.ncbi.nlm.nih.gov/pubmed/25881589
http://dx.doi.org/10.4103/0366-6999.155049
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author Xue, Yan
Zhou, Li-Ya
Lin, San-Ren
Hou, Xiao-Hua
Li, Zhao-Shen
Chen, Min-Hu
Yan, Xiu-E
Meng, Ling-Mei
Zhang, Jing
Lu, Jing-Jing
author_facet Xue, Yan
Zhou, Li-Ya
Lin, San-Ren
Hou, Xiao-Hua
Li, Zhao-Shen
Chen, Min-Hu
Yan, Xiu-E
Meng, Ling-Mei
Zhang, Jing
Lu, Jing-Jing
author_sort Xue, Yan
collection PubMed
description BACKGROUND: Helicobacter pylori (H. pylori) frequently colonizes the stomach. Gastroesophageal reflux disease (GERD) is a common and costly disease. But the relationship of H. pylori and GERD is still unclear. This study aimed to explore the effect of H. pylori and its eradication on reflux esophagitis therapy. METHODS: Patients diagnosed with reflux esophagitis by endoscopy were enrolled; based on rapid urease test and Warth–Starry stain, they were divided into H. pylori positive and negative groups. H. pylori positive patients were randomly given H. pylori eradication treatment for 10 days, then esomeprazole 20 mg bid for 46 days. The other patients received esomeprazole 20 mg bid therapy for 8 weeks. After treatment, three patient groups were obtained: H. pylori positive eradicated, H. pylori positive uneradicated, and H. pylori negative. Before and after therapy, reflux symptoms were scored and compared. Healing rates were compared among groups. The χ(2) test and t-test were used, respectively, for enumeration and measurement data. RESULTS: There were 176 H. pylori positive (with 92 eradication cases) and 180 negative cases. Healing rates in the H. pylori positive eradicated and H. pylori positive uneradicated groups reached 80.4% and 79.8% (P = 0.911), with reflux symptom scores of 0.22 and 0.14 (P = 0.588). Healing rates of esophagitis in the H. pylori positive uneradicated and H. pylori negative groups were, respectively, 79.8% and 82.2% (P = 0.848); reflux symptom scores were 0.14 and 0.21 (P = 0.546). CONCLUSIONS: Based on esomeprazole therapy, H. pylori infection and eradication have no significant effect on reflux esophagitis therapy.
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spelling pubmed-48329602016-04-29 Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy: A Multi-center Randomized Control Study Xue, Yan Zhou, Li-Ya Lin, San-Ren Hou, Xiao-Hua Li, Zhao-Shen Chen, Min-Hu Yan, Xiu-E Meng, Ling-Mei Zhang, Jing Lu, Jing-Jing Chin Med J (Engl) Original Article BACKGROUND: Helicobacter pylori (H. pylori) frequently colonizes the stomach. Gastroesophageal reflux disease (GERD) is a common and costly disease. But the relationship of H. pylori and GERD is still unclear. This study aimed to explore the effect of H. pylori and its eradication on reflux esophagitis therapy. METHODS: Patients diagnosed with reflux esophagitis by endoscopy were enrolled; based on rapid urease test and Warth–Starry stain, they were divided into H. pylori positive and negative groups. H. pylori positive patients were randomly given H. pylori eradication treatment for 10 days, then esomeprazole 20 mg bid for 46 days. The other patients received esomeprazole 20 mg bid therapy for 8 weeks. After treatment, three patient groups were obtained: H. pylori positive eradicated, H. pylori positive uneradicated, and H. pylori negative. Before and after therapy, reflux symptoms were scored and compared. Healing rates were compared among groups. The χ(2) test and t-test were used, respectively, for enumeration and measurement data. RESULTS: There were 176 H. pylori positive (with 92 eradication cases) and 180 negative cases. Healing rates in the H. pylori positive eradicated and H. pylori positive uneradicated groups reached 80.4% and 79.8% (P = 0.911), with reflux symptom scores of 0.22 and 0.14 (P = 0.588). Healing rates of esophagitis in the H. pylori positive uneradicated and H. pylori negative groups were, respectively, 79.8% and 82.2% (P = 0.848); reflux symptom scores were 0.14 and 0.21 (P = 0.546). CONCLUSIONS: Based on esomeprazole therapy, H. pylori infection and eradication have no significant effect on reflux esophagitis therapy. Medknow Publications & Media Pvt Ltd 2015-04-20 /pmc/articles/PMC4832960/ /pubmed/25881589 http://dx.doi.org/10.4103/0366-6999.155049 Text en Copyright: © 2015 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Xue, Yan
Zhou, Li-Ya
Lin, San-Ren
Hou, Xiao-Hua
Li, Zhao-Shen
Chen, Min-Hu
Yan, Xiu-E
Meng, Ling-Mei
Zhang, Jing
Lu, Jing-Jing
Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy: A Multi-center Randomized Control Study
title Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy: A Multi-center Randomized Control Study
title_full Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy: A Multi-center Randomized Control Study
title_fullStr Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy: A Multi-center Randomized Control Study
title_full_unstemmed Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy: A Multi-center Randomized Control Study
title_short Effect of Helicobacter pylori Eradication on Reflux Esophagitis Therapy: A Multi-center Randomized Control Study
title_sort effect of helicobacter pylori eradication on reflux esophagitis therapy: a multi-center randomized control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832960/
https://www.ncbi.nlm.nih.gov/pubmed/25881589
http://dx.doi.org/10.4103/0366-6999.155049
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