Data supporting the role of Fyn in initiating myelination in the peripheral nervous system

Transgenic mice, which express active Fyn tyrosine kinase under the control of a glial fibrillary acidic protein promoter, have been produced. This promoter induces protein expression in the initiation stage of myelination in the peripheral nervous system (PNS) “Phosphorylation of cytohesin-1 by Fyn...

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Detalles Bibliográficos
Autores principales: Miyamoto, Yuki, Tamano, Moe, Torii, Tomohiro, Kawahara, Kazuko, Nakamura, Kazuaki, Tanoue, Akito, Takada, Shuji, Yamauchi, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833127/
https://www.ncbi.nlm.nih.gov/pubmed/27115022
http://dx.doi.org/10.1016/j.dib.2016.03.096
Descripción
Sumario:Transgenic mice, which express active Fyn tyrosine kinase under the control of a glial fibrillary acidic protein promoter, have been produced. This promoter induces protein expression in the initiation stage of myelination in the peripheral nervous system (PNS) “Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development (Yamauchi et al., 2015 [1])”. Herein we provide the data regarding myelination-related protein markers and myelin ultrastructure in transgenic mice.

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