MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4

Mammalian sirtuins are involved in the control of metabolism and life-span regulation. Here, we link the mitochondrial sirtuin SIRT4 with cellular senescence, skin aging, and mitochondrial dysfunction. SIRT4 expression significantly increased in human dermal fibroblasts undergoing replicative or str...

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Detalles Bibliográficos
Autores principales: Lang, Alexander, Grether-Beck, Susanne, Singh, Madhurendra, Kuck, Fabian, Jakob, Sascha, Kefalas, Andreas, Altinoluk-Hambüchen, Simone, Graffmann, Nina, Schneider, Maren, Lindecke, Antje, Brenden, Heidi, Felsner, Ingo, Ezzahoini, Hakima, Marini, Alessandra, Weinhold, Sandra, Vierkötter, Andrea, Tigges, Julia, Schmidt, Stephan, Stühler, Kai, Köhrer, Karl, Uhrberg, Markus, Haendeler, Judith, Krutmann, Jean, Piekorz, Roland P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833141/
https://www.ncbi.nlm.nih.gov/pubmed/26959556
http://dx.doi.org/10.18632/aging.100905

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