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Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid

Standardized extracts of Bacopa monniera (BME) have been shown to exert a neuroprotective effect against mental diseases, such as depression, anxiety and Alzheimer's disease (AD), in chronic administration studies. However, its mechanism of action has remained unclear. In this study, we evaluat...

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Autores principales: Li, Yuanyuan, Yuan, Xing, Shen, Yunheng, Zhao, Jing, Yue, Rongcai, Liu, Fang, He, Weiwei, Wang, Rui, Shan, Lei, Zhang, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833143/
https://www.ncbi.nlm.nih.gov/pubmed/26946062
http://dx.doi.org/10.18632/aging.100913
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author Li, Yuanyuan
Yuan, Xing
Shen, Yunheng
Zhao, Jing
Yue, Rongcai
Liu, Fang
He, Weiwei
Wang, Rui
Shan, Lei
Zhang, Weidong
author_facet Li, Yuanyuan
Yuan, Xing
Shen, Yunheng
Zhao, Jing
Yue, Rongcai
Liu, Fang
He, Weiwei
Wang, Rui
Shan, Lei
Zhang, Weidong
author_sort Li, Yuanyuan
collection PubMed
description Standardized extracts of Bacopa monniera (BME) have been shown to exert a neuroprotective effect against mental diseases, such as depression, anxiety and Alzheimer's disease (AD), in chronic administration studies. However, its mechanism of action has remained unclear. In this study, we evaluated the therapeutic effect of Bacopaside I (BS-I), a major triterpenoid saponin of BME, on the cognitive impairment and neuropathology in APP/PS1 transgenic mice and explored the possible mechanism from a biological systems perspective. We found that BS-I treatment significantly ameliorated learning deficits, improved long-term spatial memory, and reduced plaque load in APP/PS1 mice. We constructed BS-I's therapeutic effect network by mapping the nodes onto the protein-protein interaction (PPI) network constructed according to their functional categories based on genomic and proteomic data. Because many of the top enrichment categories related to the processes of the immune system and phagocytosis were detected, we proposed that BS-I promotes amyloid clearance via the induction of a suitable degree of innate immune stimulation and phagocytosis. Our research may help to clarify the neuroprotective effect of BME and indicated that natural saponins target the immune system, which may offer new research avenues to discover novel treatments for AD.
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spelling pubmed-48331432016-04-20 Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid Li, Yuanyuan Yuan, Xing Shen, Yunheng Zhao, Jing Yue, Rongcai Liu, Fang He, Weiwei Wang, Rui Shan, Lei Zhang, Weidong Aging (Albany NY) Research Paper Standardized extracts of Bacopa monniera (BME) have been shown to exert a neuroprotective effect against mental diseases, such as depression, anxiety and Alzheimer's disease (AD), in chronic administration studies. However, its mechanism of action has remained unclear. In this study, we evaluated the therapeutic effect of Bacopaside I (BS-I), a major triterpenoid saponin of BME, on the cognitive impairment and neuropathology in APP/PS1 transgenic mice and explored the possible mechanism from a biological systems perspective. We found that BS-I treatment significantly ameliorated learning deficits, improved long-term spatial memory, and reduced plaque load in APP/PS1 mice. We constructed BS-I's therapeutic effect network by mapping the nodes onto the protein-protein interaction (PPI) network constructed according to their functional categories based on genomic and proteomic data. Because many of the top enrichment categories related to the processes of the immune system and phagocytosis were detected, we proposed that BS-I promotes amyloid clearance via the induction of a suitable degree of innate immune stimulation and phagocytosis. Our research may help to clarify the neuroprotective effect of BME and indicated that natural saponins target the immune system, which may offer new research avenues to discover novel treatments for AD. Impact Journals LLC 2016-03-02 /pmc/articles/PMC4833143/ /pubmed/26946062 http://dx.doi.org/10.18632/aging.100913 Text en Copyright: © 2016 Li et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Li, Yuanyuan
Yuan, Xing
Shen, Yunheng
Zhao, Jing
Yue, Rongcai
Liu, Fang
He, Weiwei
Wang, Rui
Shan, Lei
Zhang, Weidong
Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid
title Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid
title_full Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid
title_fullStr Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid
title_full_unstemmed Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid
title_short Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid
title_sort bacopaside i ameliorates cognitive impairment in app/ps1 mice via immune-mediated clearance of β-amyloid
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833143/
https://www.ncbi.nlm.nih.gov/pubmed/26946062
http://dx.doi.org/10.18632/aging.100913
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