Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease

A sputum eosinophilia is observed in 10–40% of COPD subjects. The blood eosinophil count is a biomarker of sputum eosinophilia, but whether it is associated with bronchial submucosal eosinophils is unclear. In 20 COPD subjects and 21 controls we assessed the number of bronchial submucosal eosinophil...

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Autores principales: Eltboli, Osama, Mistry, Vijay, Barker, Bethan, Brightling, Chris E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Scientific Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833195/
https://www.ncbi.nlm.nih.gov/pubmed/25645275
http://dx.doi.org/10.1111/resp.12475
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author Eltboli, Osama
Mistry, Vijay
Barker, Bethan
Brightling, Chris E.
author_facet Eltboli, Osama
Mistry, Vijay
Barker, Bethan
Brightling, Chris E.
author_sort Eltboli, Osama
collection PubMed
description A sputum eosinophilia is observed in 10–40% of COPD subjects. The blood eosinophil count is a biomarker of sputum eosinophilia, but whether it is associated with bronchial submucosal eosinophils is unclear. In 20 COPD subjects and 21 controls we assessed the number of bronchial submucosal eosinophils and reticular basement membrane thickening and found these were positively correlated with the blood eosinophil percentage. In COPD, blood eosinophils are a good biomarker of bronchial eosinophilia and remodelling.
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spelling pubmed-48331952016-06-24 Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease Eltboli, Osama Mistry, Vijay Barker, Bethan Brightling, Chris E. Respirology Scientific Letters A sputum eosinophilia is observed in 10–40% of COPD subjects. The blood eosinophil count is a biomarker of sputum eosinophilia, but whether it is associated with bronchial submucosal eosinophils is unclear. In 20 COPD subjects and 21 controls we assessed the number of bronchial submucosal eosinophils and reticular basement membrane thickening and found these were positively correlated with the blood eosinophil percentage. In COPD, blood eosinophils are a good biomarker of bronchial eosinophilia and remodelling. John Wiley and Sons Inc. 2015-05 2015-01-27 /pmc/articles/PMC4833195/ /pubmed/25645275 http://dx.doi.org/10.1111/resp.12475 Text en © 2015 The Authors. Respirology published by Wiley Publishing Asia Pty Ltd on behalf of Asian Pacific Society of Respirology. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Scientific Letters
Eltboli, Osama
Mistry, Vijay
Barker, Bethan
Brightling, Chris E.
Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease
title Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease
title_full Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease
title_fullStr Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease
title_full_unstemmed Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease
title_short Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease
title_sort relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease
topic Scientific Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833195/
https://www.ncbi.nlm.nih.gov/pubmed/25645275
http://dx.doi.org/10.1111/resp.12475
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