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Posterior Parietal Cortex Drives Inferotemporal Activations During Three-Dimensional Object Vision

The primate visual system consists of a ventral stream, specialized for object recognition, and a dorsal visual stream, which is crucial for spatial vision and actions. However, little is known about the interactions and information flow between these two streams. We investigated these interactions...

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Autores principales: Van Dromme, Ilse C., Premereur, Elsie, Verhoef, Bram-Ernst, Vanduffel, Wim, Janssen, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833303/
https://www.ncbi.nlm.nih.gov/pubmed/27082854
http://dx.doi.org/10.1371/journal.pbio.1002445
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author Van Dromme, Ilse C.
Premereur, Elsie
Verhoef, Bram-Ernst
Vanduffel, Wim
Janssen, Peter
author_facet Van Dromme, Ilse C.
Premereur, Elsie
Verhoef, Bram-Ernst
Vanduffel, Wim
Janssen, Peter
author_sort Van Dromme, Ilse C.
collection PubMed
description The primate visual system consists of a ventral stream, specialized for object recognition, and a dorsal visual stream, which is crucial for spatial vision and actions. However, little is known about the interactions and information flow between these two streams. We investigated these interactions within the network processing three-dimensional (3D) object information, comprising both the dorsal and ventral stream. Reversible inactivation of the macaque caudal intraparietal area (CIP) during functional magnetic resonance imaging (fMRI) reduced fMRI activations in posterior parietal cortex in the dorsal stream and, surprisingly, also in the inferotemporal cortex (ITC) in the ventral visual stream. Moreover, CIP inactivation caused a perceptual deficit in a depth-structure categorization task. CIP-microstimulation during fMRI further suggests that CIP projects via posterior parietal areas to the ITC in the ventral stream. To our knowledge, these results provide the first causal evidence for the flow of visual 3D information from the dorsal stream to the ventral stream, and identify CIP as a key area for depth-structure processing. Thus, combining reversible inactivation and electrical microstimulation during fMRI provides a detailed view of the functional interactions between the two visual processing streams.
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spelling pubmed-48333032016-04-22 Posterior Parietal Cortex Drives Inferotemporal Activations During Three-Dimensional Object Vision Van Dromme, Ilse C. Premereur, Elsie Verhoef, Bram-Ernst Vanduffel, Wim Janssen, Peter PLoS Biol Research Article The primate visual system consists of a ventral stream, specialized for object recognition, and a dorsal visual stream, which is crucial for spatial vision and actions. However, little is known about the interactions and information flow between these two streams. We investigated these interactions within the network processing three-dimensional (3D) object information, comprising both the dorsal and ventral stream. Reversible inactivation of the macaque caudal intraparietal area (CIP) during functional magnetic resonance imaging (fMRI) reduced fMRI activations in posterior parietal cortex in the dorsal stream and, surprisingly, also in the inferotemporal cortex (ITC) in the ventral visual stream. Moreover, CIP inactivation caused a perceptual deficit in a depth-structure categorization task. CIP-microstimulation during fMRI further suggests that CIP projects via posterior parietal areas to the ITC in the ventral stream. To our knowledge, these results provide the first causal evidence for the flow of visual 3D information from the dorsal stream to the ventral stream, and identify CIP as a key area for depth-structure processing. Thus, combining reversible inactivation and electrical microstimulation during fMRI provides a detailed view of the functional interactions between the two visual processing streams. Public Library of Science 2016-04-15 /pmc/articles/PMC4833303/ /pubmed/27082854 http://dx.doi.org/10.1371/journal.pbio.1002445 Text en © 2016 Van Dromme et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Van Dromme, Ilse C.
Premereur, Elsie
Verhoef, Bram-Ernst
Vanduffel, Wim
Janssen, Peter
Posterior Parietal Cortex Drives Inferotemporal Activations During Three-Dimensional Object Vision
title Posterior Parietal Cortex Drives Inferotemporal Activations During Three-Dimensional Object Vision
title_full Posterior Parietal Cortex Drives Inferotemporal Activations During Three-Dimensional Object Vision
title_fullStr Posterior Parietal Cortex Drives Inferotemporal Activations During Three-Dimensional Object Vision
title_full_unstemmed Posterior Parietal Cortex Drives Inferotemporal Activations During Three-Dimensional Object Vision
title_short Posterior Parietal Cortex Drives Inferotemporal Activations During Three-Dimensional Object Vision
title_sort posterior parietal cortex drives inferotemporal activations during three-dimensional object vision
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833303/
https://www.ncbi.nlm.nih.gov/pubmed/27082854
http://dx.doi.org/10.1371/journal.pbio.1002445
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