CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells

Plasmacytoid dendritic cells (pDC) are innate immune cells that sense viral nucleic acids through endosomal Toll-like receptor (TLR) 7/9 to produce type I interferon (IFN) and to differentiate into potent antigen presenting cells (APC). Engagement of TLR7/9 in early endosomes appears to trigger the...

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Detalles Bibliográficos
Autores principales: O’Brien, Meagan, Manches, Olivier, Wilen, Craig, Gopal, Ramya, Huq, Rumana, Wu, Vernon, Sunseri, Nicole, Bhardwaj, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833349/
https://www.ncbi.nlm.nih.gov/pubmed/27082754
http://dx.doi.org/10.1371/journal.ppat.1005553

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