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Decreased Polycystin 2 Levels Result in Non-Renal Cardiac Dysfunction with Aging
Mutations in the gene for polycystin 2 (Pkd2) lead to polycystic kidney disease, however the main cause of mortality in humans is cardiac related. We previously showed that 5 month old Pkd2+/- mice have altered calcium-contractile activity in cardiomyocytes, but have preserved cardiac function. Here...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833351/ https://www.ncbi.nlm.nih.gov/pubmed/27081851 http://dx.doi.org/10.1371/journal.pone.0153632 |