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Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension
OBJECTIVES: Central hemodynamics may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to cardiovascular outcomes. METHODS: Patients who had confirmed hypertension as assessed by daytime 24-hour ambulatory blood pressure monitoring (≥135...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833369/ https://www.ncbi.nlm.nih.gov/pubmed/27114704 http://dx.doi.org/10.2147/CIA.S101302 |
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author | Ahn, Kye Taek Park, Kwang-In Kim, Mi Joo Oh, Jin Kyung Han, Ji Hye Kwon, Hee Jin Jin, Seon-Ah Kim, Jun-Hyung Park, Jae-Hyeong Lee, Jae-Hwan Choi, Si Wan Seong, In-Whan Jeong, Jin-Ok |
author_facet | Ahn, Kye Taek Park, Kwang-In Kim, Mi Joo Oh, Jin Kyung Han, Ji Hye Kwon, Hee Jin Jin, Seon-Ah Kim, Jun-Hyung Park, Jae-Hyeong Lee, Jae-Hwan Choi, Si Wan Seong, In-Whan Jeong, Jin-Ok |
author_sort | Ahn, Kye Taek |
collection | PubMed |
description | OBJECTIVES: Central hemodynamics may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to cardiovascular outcomes. METHODS: Patients who had confirmed hypertension as assessed by daytime 24-hour ambulatory blood pressure monitoring (≥135/85 mmHg) were enrolled. Central blood pressure and radial augmentation index (AIx) corrected for a heart rate of 75 bpm (radial AIx 75) were measured for all patients. We evaluated the association of age, height, and sex with central hemodynamics in patients with never-treated hypertension. RESULTS: A total of 203 patients were enrolled, of whom men numbered 101 (49.7%). The median height of all patients was 162 cm, and mean age was 53.2 years. In the Pearson correlation analysis, regardless of sex difference (R=−0.627 for height, R=0.035 for age, P-value =0.005), a stronger relationship was observed between height and radial AIx 75 than between age and radial AIx 75. In the multiple regression analysis, the sex difference and height were strongly associated with elevated radial AIx 75 in all patients (adjusted R(2)=0.428, β=6.237, 95% confidence interval [CI] for women 1.480–10.995, P-value =0.011 and β=−0.632, 95% CI for height −0.929 to −0.335, P-value =0.009, respectively). CONCLUSION: In patients with never-treated hypertension, female sex and shorter height are the important risk factors of elevated radial AIx 75. |
format | Online Article Text |
id | pubmed-4833369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48333692016-04-25 Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension Ahn, Kye Taek Park, Kwang-In Kim, Mi Joo Oh, Jin Kyung Han, Ji Hye Kwon, Hee Jin Jin, Seon-Ah Kim, Jun-Hyung Park, Jae-Hyeong Lee, Jae-Hwan Choi, Si Wan Seong, In-Whan Jeong, Jin-Ok Clin Interv Aging Original Research OBJECTIVES: Central hemodynamics may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to cardiovascular outcomes. METHODS: Patients who had confirmed hypertension as assessed by daytime 24-hour ambulatory blood pressure monitoring (≥135/85 mmHg) were enrolled. Central blood pressure and radial augmentation index (AIx) corrected for a heart rate of 75 bpm (radial AIx 75) were measured for all patients. We evaluated the association of age, height, and sex with central hemodynamics in patients with never-treated hypertension. RESULTS: A total of 203 patients were enrolled, of whom men numbered 101 (49.7%). The median height of all patients was 162 cm, and mean age was 53.2 years. In the Pearson correlation analysis, regardless of sex difference (R=−0.627 for height, R=0.035 for age, P-value =0.005), a stronger relationship was observed between height and radial AIx 75 than between age and radial AIx 75. In the multiple regression analysis, the sex difference and height were strongly associated with elevated radial AIx 75 in all patients (adjusted R(2)=0.428, β=6.237, 95% confidence interval [CI] for women 1.480–10.995, P-value =0.011 and β=−0.632, 95% CI for height −0.929 to −0.335, P-value =0.009, respectively). CONCLUSION: In patients with never-treated hypertension, female sex and shorter height are the important risk factors of elevated radial AIx 75. Dove Medical Press 2016-04-11 /pmc/articles/PMC4833369/ /pubmed/27114704 http://dx.doi.org/10.2147/CIA.S101302 Text en © 2016 Ahn et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Ahn, Kye Taek Park, Kwang-In Kim, Mi Joo Oh, Jin Kyung Han, Ji Hye Kwon, Hee Jin Jin, Seon-Ah Kim, Jun-Hyung Park, Jae-Hyeong Lee, Jae-Hwan Choi, Si Wan Seong, In-Whan Jeong, Jin-Ok Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension |
title | Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension |
title_full | Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension |
title_fullStr | Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension |
title_full_unstemmed | Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension |
title_short | Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension |
title_sort | height and sex is strongly associated with radial augmentation index in korean patients with never-treated hypertension |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833369/ https://www.ncbi.nlm.nih.gov/pubmed/27114704 http://dx.doi.org/10.2147/CIA.S101302 |
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