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Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension

OBJECTIVES: Central hemodynamics may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to cardiovascular outcomes. METHODS: Patients who had confirmed hypertension as assessed by daytime 24-hour ambulatory blood pressure monitoring (≥135...

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Autores principales: Ahn, Kye Taek, Park, Kwang-In, Kim, Mi Joo, Oh, Jin Kyung, Han, Ji Hye, Kwon, Hee Jin, Jin, Seon-Ah, Kim, Jun-Hyung, Park, Jae-Hyeong, Lee, Jae-Hwan, Choi, Si Wan, Seong, In-Whan, Jeong, Jin-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833369/
https://www.ncbi.nlm.nih.gov/pubmed/27114704
http://dx.doi.org/10.2147/CIA.S101302
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author Ahn, Kye Taek
Park, Kwang-In
Kim, Mi Joo
Oh, Jin Kyung
Han, Ji Hye
Kwon, Hee Jin
Jin, Seon-Ah
Kim, Jun-Hyung
Park, Jae-Hyeong
Lee, Jae-Hwan
Choi, Si Wan
Seong, In-Whan
Jeong, Jin-Ok
author_facet Ahn, Kye Taek
Park, Kwang-In
Kim, Mi Joo
Oh, Jin Kyung
Han, Ji Hye
Kwon, Hee Jin
Jin, Seon-Ah
Kim, Jun-Hyung
Park, Jae-Hyeong
Lee, Jae-Hwan
Choi, Si Wan
Seong, In-Whan
Jeong, Jin-Ok
author_sort Ahn, Kye Taek
collection PubMed
description OBJECTIVES: Central hemodynamics may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to cardiovascular outcomes. METHODS: Patients who had confirmed hypertension as assessed by daytime 24-hour ambulatory blood pressure monitoring (≥135/85 mmHg) were enrolled. Central blood pressure and radial augmentation index (AIx) corrected for a heart rate of 75 bpm (radial AIx 75) were measured for all patients. We evaluated the association of age, height, and sex with central hemodynamics in patients with never-treated hypertension. RESULTS: A total of 203 patients were enrolled, of whom men numbered 101 (49.7%). The median height of all patients was 162 cm, and mean age was 53.2 years. In the Pearson correlation analysis, regardless of sex difference (R=−0.627 for height, R=0.035 for age, P-value =0.005), a stronger relationship was observed between height and radial AIx 75 than between age and radial AIx 75. In the multiple regression analysis, the sex difference and height were strongly associated with elevated radial AIx 75 in all patients (adjusted R(2)=0.428, β=6.237, 95% confidence interval [CI] for women 1.480–10.995, P-value =0.011 and β=−0.632, 95% CI for height −0.929 to −0.335, P-value =0.009, respectively). CONCLUSION: In patients with never-treated hypertension, female sex and shorter height are the important risk factors of elevated radial AIx 75.
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spelling pubmed-48333692016-04-25 Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension Ahn, Kye Taek Park, Kwang-In Kim, Mi Joo Oh, Jin Kyung Han, Ji Hye Kwon, Hee Jin Jin, Seon-Ah Kim, Jun-Hyung Park, Jae-Hyeong Lee, Jae-Hwan Choi, Si Wan Seong, In-Whan Jeong, Jin-Ok Clin Interv Aging Original Research OBJECTIVES: Central hemodynamics may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to cardiovascular outcomes. METHODS: Patients who had confirmed hypertension as assessed by daytime 24-hour ambulatory blood pressure monitoring (≥135/85 mmHg) were enrolled. Central blood pressure and radial augmentation index (AIx) corrected for a heart rate of 75 bpm (radial AIx 75) were measured for all patients. We evaluated the association of age, height, and sex with central hemodynamics in patients with never-treated hypertension. RESULTS: A total of 203 patients were enrolled, of whom men numbered 101 (49.7%). The median height of all patients was 162 cm, and mean age was 53.2 years. In the Pearson correlation analysis, regardless of sex difference (R=−0.627 for height, R=0.035 for age, P-value =0.005), a stronger relationship was observed between height and radial AIx 75 than between age and radial AIx 75. In the multiple regression analysis, the sex difference and height were strongly associated with elevated radial AIx 75 in all patients (adjusted R(2)=0.428, β=6.237, 95% confidence interval [CI] for women 1.480–10.995, P-value =0.011 and β=−0.632, 95% CI for height −0.929 to −0.335, P-value =0.009, respectively). CONCLUSION: In patients with never-treated hypertension, female sex and shorter height are the important risk factors of elevated radial AIx 75. Dove Medical Press 2016-04-11 /pmc/articles/PMC4833369/ /pubmed/27114704 http://dx.doi.org/10.2147/CIA.S101302 Text en © 2016 Ahn et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Ahn, Kye Taek
Park, Kwang-In
Kim, Mi Joo
Oh, Jin Kyung
Han, Ji Hye
Kwon, Hee Jin
Jin, Seon-Ah
Kim, Jun-Hyung
Park, Jae-Hyeong
Lee, Jae-Hwan
Choi, Si Wan
Seong, In-Whan
Jeong, Jin-Ok
Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension
title Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension
title_full Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension
title_fullStr Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension
title_full_unstemmed Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension
title_short Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension
title_sort height and sex is strongly associated with radial augmentation index in korean patients with never-treated hypertension
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833369/
https://www.ncbi.nlm.nih.gov/pubmed/27114704
http://dx.doi.org/10.2147/CIA.S101302
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