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Conformational Heterogeneity of Cyclosporin A in Cyclophilin 18 Binding
The immunosuppressive drug cyclosporin A (CsA) binds to its receptor protein cyclophilin 18 (Cyp18) in two distinct kinetic phases, while the mechanism remains elusive. Stopped-flow measurements coupled with titration and competition experiments were used to investigate the puzzling two-phase proces...
Autores principales: | Lin, Weilin, Quintero, Andres, Zhang, Yixin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833397/ https://www.ncbi.nlm.nih.gov/pubmed/27082870 http://dx.doi.org/10.1371/journal.pone.0153669 |
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