Structures of HIV-1-Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

Broadly neutralizing antibodies (bNAbs) against HIV-1-Env V1V2 arise in multiple donors. However, atomic-level interactions had only been determined with antibodies from a single donor, making commonalities in recognition uncertain. Here we report the co-crystal structure of V1V2 with antibody CH03...

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Detalles Bibliográficos
Autores principales: Gorman, Jason, Soto, Cinque, Yang, Max M., Davenport, Thaddeus M., Guttman, Miklos, Bailer, Robert T., Chambers, Michael, Chuang, Gwo-Yu, DeKosky, Brandon J., Doria-Rose, Nicole A., Druz, Aliaksandr, Ernandes, Michael J., Georgiev, Ivelin S., Jarosinski, Marissa C., Joyce, M. Gordon, Lemmin, Thomas M., Leung, Sherman, Louder, Mark K., McDaniel, Jonathan R., Narpala, Sandeep, Pancera, Marie, Stuckey, Jonathan, Wu, Xueling, Yang, Yongping, Zhang, Baoshan, Zhou, Tongqing, Mullikin, James C., Baxa, Ulrich, Georgiou, George, McDermott, Adrian B., Bonsignori, Mattia, Haynes, Barton F., Moore, Penny L., Morris, Lynn, Lee, Kelly K., Shapiro, Lawrence, Mascola, John R., Kwong, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833398/
https://www.ncbi.nlm.nih.gov/pubmed/26689967
http://dx.doi.org/10.1038/nsmb.3144

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