Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth

Mammalian microRNA expression is dysregulated in human cancer. However, the functional relevance of many microRNAs in the context of tumor biology remains unclear. Using CRISPR-Cas9 technology, we performed a global loss-of-function screen to simultaneously test the functions of individual microRNAs...

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Detalles Bibliográficos
Autores principales: Wallace, Jared, Hu, Ruozhen, Mosbruger, Timothy L., Dahlem, Timothy J., Stephens, W. Zac, Rao, Dinesh S., Round, June L., O’Connell, Ryan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833428/
https://www.ncbi.nlm.nih.gov/pubmed/27081855
http://dx.doi.org/10.1371/journal.pone.0153689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833428/
https://www.ncbi.nlm.nih.gov/pubmed/27081855
http://dx.doi.org/10.1371/journal.pone.0153689

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