Treatment Approach to Patients With Severe Insulin Resistance

In Brief Patients with severe insulin resistance require >2 units/kg of body weight or 200 units/day of insulin. Yet, many patients do not achieve glycemic targets despite using very high doses of insulin. Insulin can cause weight gain, which further contributes to worsening insulin resistance. T...

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Detalles Bibliográficos
Autores principales: Church, Timothy J., Haines, Stuart T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Feature Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833480/
https://www.ncbi.nlm.nih.gov/pubmed/27092020
http://dx.doi.org/10.2337/diaclin.34.2.97
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author Church, Timothy J.
Haines, Stuart T.
author_facet Church, Timothy J.
Haines, Stuart T.
author_sort Church, Timothy J.
collection PubMed
description In Brief Patients with severe insulin resistance require >2 units/kg of body weight or 200 units/day of insulin. Yet, many patients do not achieve glycemic targets despite using very high doses of insulin. Insulin can cause weight gain, which further contributes to worsening insulin resistance. This article describes the pharmacological options for managing patients with severe insulin resistance, including the use of U-500 insulin and newer agents in combination with insulin.
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spelling pubmed-48334802017-04-01 Treatment Approach to Patients With Severe Insulin Resistance Church, Timothy J. Haines, Stuart T. Clin Diabetes Feature Articles In Brief Patients with severe insulin resistance require >2 units/kg of body weight or 200 units/day of insulin. Yet, many patients do not achieve glycemic targets despite using very high doses of insulin. Insulin can cause weight gain, which further contributes to worsening insulin resistance. This article describes the pharmacological options for managing patients with severe insulin resistance, including the use of U-500 insulin and newer agents in combination with insulin. American Diabetes Association 2016-04 /pmc/articles/PMC4833480/ /pubmed/27092020 http://dx.doi.org/10.2337/diaclin.34.2.97 Text en © 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0 for details.
spellingShingle Feature Articles
Church, Timothy J.
Haines, Stuart T.
Treatment Approach to Patients With Severe Insulin Resistance
title Treatment Approach to Patients With Severe Insulin Resistance
title_full Treatment Approach to Patients With Severe Insulin Resistance
title_fullStr Treatment Approach to Patients With Severe Insulin Resistance
title_full_unstemmed Treatment Approach to Patients With Severe Insulin Resistance
title_short Treatment Approach to Patients With Severe Insulin Resistance
title_sort treatment approach to patients with severe insulin resistance
topic Feature Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833480/
https://www.ncbi.nlm.nih.gov/pubmed/27092020
http://dx.doi.org/10.2337/diaclin.34.2.97
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