Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary...

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Detalles Bibliográficos
Autores principales: Hellquist, Henrik, Skálová, Alena, Barnes, Leon, Cardesa, Antonio, Thompson, Lester D. R., Triantafyllou, Asterios, Williams, Michelle D., Devaney, Kenneth O., Gnepp, Douglas R., Bishop, Justin A., Wenig, Bruce M., Suárez, Carlos, Rodrigo, Juan P., Coca-Pelaz, Andrés, Strojan, Primož, Shah, Jatin P., Hamoir, Marc, Bradley, Patrick J., Silver, Carl E., Slootweg, Pieter J., Vander Poorten, Vincent, Teymoortash, Afshin, Medina, Jesus E., Robbins, K. Thomas, Pitman, Karen T., Kowalski, Luiz P., de Bree, Remco, Mendenhall, William M., Eloy, Jean Anderson, Takes, Robert P., Rinaldo, Alessandra, Ferlito, Alfio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833802/
https://www.ncbi.nlm.nih.gov/pubmed/26895332
http://dx.doi.org/10.1007/s12325-016-0298-5
Descripción
Sumario:Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC–HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12325-016-0298-5) contains supplementary material, which is available to authorized users.

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